Hematopoietic Organs

Question 1

four major cell types in the marrow

Answer 1

erythroid elements - RBC’s

myeloid elements - white cells (neutrophils, eoinophils, basophils, monocytes)

megakaryocytes - platalets

lymphocytes - B cells, T cells, plasma cells

Question 2

peripheral blood

Answer 2

bone marrow

Question 3

lymph node

Answer 3

lymphoid tissue

Question 4

leukemia

Answer 4

“white blood” the presence of circulating abnormal cells in the blood (not normal likely immature white cells)

Question 5

two major pathways in hematopoiesis

Answer 5

1. self renewal (lack of renewal will lead to anemia)
2. Maturation sequence pathways

IMPORTANT THERE IS BALANCE IN THESE TWO SYSTEMS

Question 6

acute leukemia

Answer 6

circulating blasts (immature stage) of either myeloid (neutrophils, eosinophils, basophils, monocytes) origin or lymphoid origin (T and B cells, plasma cells)

Question 7

acute myelogenous leukemia

AML

Answer 7

acute leukemia of myeloid origin

-

Question 8

acute lymphoblastic leukemia

ALL

Answer 8

acute leukemia from lymphoid origin - circulating immature B, T or plasma cells

Question 9

chronic leukemia

Answer 9

circulating mature cells of myeloid origin or lymphoid origin

Question 10

histo of lymphoblasts

Answer 10

mostly round nuclei, condensed chromatin, single nucleoli and scant agranular cytoplams

Question 11

chronic myelogenous leukemia

Answer 11

CML

Question 12

chronic myelogenous leukemia

Answer 12

CML

associated with a philadelphia chromosomal translocation of 9 and 22

Question 13

how you differentiate between chronic and acute lymphoma

Answer 13

crucial distinction is acute are BLASTS, and chronic - there are more mature cells