HEMATOPOIESIS [MEDULLARY PHASE]

Question 1

This phase starts at the 16-18th week of gestation.

The bone marrow becomes the primary site of hematopoiesis between 5th and 6th month of gestation.

Continues a the primary source of blood production after birth and throughout life.

Answer 1

Medullary or Myeloid Phase

Question 2

This is the marrow in the first few years of life and as we age, it undergoes retrogression.

This is active during the hematopoietic process and are arranged in cords.

Answer 2

Red Marrow

Question 3

This is the process wherein yellow marrow becomes red marrow.

Answer 3

Retrogression

Question 4

This kind of marrow contains adipocytes.

Answer 4

Yellow Marrow

Question 5

These are defined as helpers of hematopoiesis.

Answer 5

Hematopoietic Elements

Question 6

This plays an important rolse in nurturing and protecting HSC’s.

There is the prescence of different types of components like collagen, fibronectic, osteoclasts, etc.

Answer 6

Unique Microenvironment

Question 7

What is an example of a factor that help stimulate hematopoiesis in the bone marrow.

These are produced in the kidneys and it triggers our HSC in order to develop into erythrocytes.

Answer 7

Erythropoietin

Question 8

In the medullary phase, what are the site, onset, at birth, 4 years old, 16 years old?

Answer 8

SITE: Bone Marrow

ONSET: 5th and 6th month of gestation.
Primary site by the end of the 24 weeks

AT BIRTH: Primary source of cell production.

4 Y/O: Formation of fatty reserves.

18 Y/O: Only active tissues are:
- Pelvis
- Ribs
- Skull
- Vertebrae
- Sternum
- Proximal extremities of the long bone (Femur & Humerus).

Question 9

This is the principal site of blood cell production in the bone marrow.

Answer 9

Sternum

Question 10

What are the detectable compounds during the medually phase?

Answer 10

• Erythropoietin
• Garnulocyte colony-stimulating factor (G-CSF)
• Granulocyte-macrophage colony-stimulating factor (GM-CSF)
• Hemoglobin F and Adult Hemoglobin

Question 11

This is when the production of blood cells are confined in the bone marrow.

Answer 11

Medullay Hematopoiesis

Question 12

This is when the liver and spleen may become as the site of hematopoiesis.

Can only occur in hemolytic anemias, wherein there is an increased demand placed on the bone marrow.

Answer 12

Extramedullary Hematopoiesis