HEMATOPOIESIS [ADULT HEMATOPOIETIC TISSUES] Flashcards
This is one of the largest organs in the body. The volume of increases from 1.5% to 4.5% in adults.
Composed of two types, red and yellow.
Consists of trabeulae.
Bone Marrow
These are projections of calcified bone and provides support for the developing cells.
Trabeculae
These are hematopoietically active marrows.
Consists the developing blood cells and their progenitors.
During infancy and early childhood, all bones in body contain primarily of this kind of marrow.
The main puncture site is the Iliac Crest of the Pelvis.
Red Marrow
This is the puncture site when aspirating red marrow.
Illiac Crest of the Pelvis
Only physicians can aspirate from this site.
These are hematopoietically inactive marrows.
Comprised mostly of adipocytes or fat cells.
Well differentiated mesenchymal cells and macrophages.
Between 5 and 7 years of age, the adipocytes become more abundant and occupies the other type of marrow (retrogression).
Yellow Marrow
This is the major site of blood cell production during the second trimester of fetal development.
In adults:
- Protein synthesis and degradation.
- Coagulation factor synthesis.
- Carb and fat metabolism.
- Drug and toxin clearance.
- Iron recycling and storage.
- Hemogobin degredatiom (bilirubin)
- Directly affected by Kupffer cells.
Liver
This is the largest secondary lymphoid organ in the body.
Indiscriminately filters blood and contains about 350mL of blood.
Can store blood cells and be released on demand, although monocytes is not contained in the pheripheral blood, it migrates to tissues where they become macrophages via mononuclear phagocyte system.
This organ also has the ability to do pitting, culling, and platelet storage.
Spleen
What are the three types of splenic tissues?
- White Pulp
- Red Pulp
- Marginal Zone
This tissue contains lymphocytes, macrophages, and dendritic cells.
White Pulp
This tissue filters the blood that passes through the region.
Red Pulp
This surrounds the white pulp.
Forms a reticular meshwork containing blood vessels, macrophages, memory B cells, and CD4+ T cells.
Marginal Zone
The approximate percentage of the total plaetlet count sequestered in the spleen.
30%
This is is a system that functions to destroy cellular components the body can still use, such as iron and globin from RBC’s.
Reticuloendothelial System (RES)
This organ is bean-shaped and serves three main functions:
- Site of lymphocyte proliferation from germinal centers.
- Involved in the initiation of specific immune respone to foreign antigens.
- Filter particulate matter, debris, and bacteria entering the nodes via lymph.
Lymph Nodes
This is the organ wherein T cell progenitors migrate to, coming from the bone marrow for further maturation.
Thymus
