HEMATOPOIESIS [HSC] Flashcards
These are defined at the single-cell level by their dual capacity for self renewal and multipotent differentiation.
Renewals have short-term and long-term repopulating cells (STR and LTR).
Their Colony Forming Unit - Spleen. Earliest primitive cell type.
All cells come from a singe cell called the totipotent stem cell.
They give rise to multipotent progenitors.
This has 2 true basic characteristics:
- Self-maintaining with high proliferativity
- Gives rise to further differentiated cells.
Hematopoietic Stem Cells
What are the 2 characteristics of a true stem cell?
- Self-maintaining with high proliferative capability.
- Ability to give rise to differentiated cells.
Totiponent stem cells becomes (?).
Pluripotent Stem Cell
These kinds of stem cells are restricted to a specific line of development.
They have limited proliferative activity.
Commited Stem Cells
These have reduced self-renewal potential. They also spend much less time in G0 and are highly proliferative.
Progenitors
These are the progenitors of the T, B, natural killer lymphocytes, and dendritic lineages.
Common Lymphoid Progenitor
These are the progenitors for the granulocytic, erythrocytic, monocytic, and megakaryocytic lineages.
Common Myeloid Progenitor
(?) are indistinguishable from one another.
(?) are cells that mature immediately.
(?) are also called precursor cells.
(Stem Cells) are indistinguishable from one another.
(Progenitor Cells) are cells that mature immediately.
(Maturing Cells) are also called precursor cells.
Mulitpotent stem cells can proliferate via (?) and can differentiate along any cell line.
Mitosis
(?) and (?) have the same lineage and only depends on their progenitor.
(Megakaryopoiesis) and (Erythropoiesis) have the same lineage and only depends on their progenitor.
These are precursor cells that are commited and restrited to a certain precursor.
Lineage-specific Precursor Cell
