HEMATOPOIESIS [HEPATIC PHASE]

Question 1

This phase starts at the 3rd month of fetal life and the liver becomes the chief site of blood cell production.

Other sites are the spleen, thymus, and lymph nodes.

Hemoglobin F is the predominant type of hemoglobin during this phase.

Megakaryocytes production begins in this phase.

The spleen contributes solely to lymphoiesis.

Answer 1

Hepatic Phase

Question 2

This is the predominant type of hemoglobin that can be seen in the hepatic phase.

Answer 2

Hemoglobin F

Question 3

This is the first fully developed organ in the fetus.

Major site of T cell production.

Answer 3

Thymus

Question 4

These organs produces B cells.

Answer 4

Kindeys and Spleen

Question 5

These are formed extravasculary, exclude their nucleus, and contains hemoglobin F.

Answer 5

Definitive Erythrocytes

Question 6

In the hepatic phase, what are the sites, onset, peak, decline, and cells produced?

Answer 6

SITE: Fetal Liver (Primary), Spleen, and Thymus

ONSET: 5th to 7th week of gestation.

PEAK: 3rd month of fetal development.

DECLINE: Gradually after 6th month until 1 to 2 weeks after birth.

CELLS PRODUCED:
- Definitive Erythroblasts
- Megakaryocytes
- Granulocytes

Question 7

These are the emrbyonic hemoglobin in the hepatic phase.

Answer 7

Fetal Hemobglobin (HBF): 2 Alpha + 2 Gamma
Adult Hemoglobin (A1): 2 Alpha + 2 Beta
Adult Hemoglobin (A2): 2 Alpha + 2 Delta

Question 8

This organ functions as the blood empties into the cords of the red pulp in a slow transit pathway. It has a culling an pitting function.

These pulps ‘squeeze’ the erythrocytes in order to check if they are still functional

Answer 8

Spleen

Question 9

This is the spleen’s ability to filter and destroy senescent (old) or damaged red cells.

Answer 9

Culling

Question 10

This is the spleen’s ability to “pluck out” particles from intact erythrocytes without destroying them.

This is especially used for RBC inclusions (foreign material inside RBC’s)

Answer 10

Pitting