Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Bio 153 midterm lecture > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

what is hematopoiesis

A

formation of blood cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is a hemocytoblast

A

stem cell that differentiates into all formed elements of blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is leukopoiesis

A

formation of leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is leukopoiesis regulated by

A

cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are cytokines

A

cells signalling molecules called colony stimulating factors (varies in response to immune system)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is thrombocytopoiesis

A

formation of thrombocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is erythropoiesis

A

formation of RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How long does it take to make an RBC

A

3-5 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

how many new ones are made a day

A

2 million a second (15ml a day)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what does testosterone do to RBC production

A

enhances RBC production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What mineral does erythropoiesis require

A

iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is inside a hemoglobin (hb)

A
  • globin proteins: 2 Alpha, 2 Beta

- 4 hemes with iron inside a porphyrin ring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How many O2 and CO2 can each hb bind

A

4 O2, 4 CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What controls erythropoiesis

A

a glycoprotein called erythropoietin (EPO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is EPO secreted from

A

kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

why is EPO secreted

A

in response to hypoxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the 3 reasons for hypoxia

A

Blood loss
decreased O2 in blood
increased demand of O2

18
Q

What happens to RBCs w/ age

A
  • less flexible & fragile

- Reduced O2 carrying capability

19
Q

What is a RBC lifespan

A

120 days

20
Q

What is the liver and spleens role in recycling RBCS

A

they trap the old ones

21
Q

What is the role of macrophages in the liver and spleen

A

they phagocytic RBC in liver and spleen to recycle RBC

22
Q

1st step of all hematopoiesis?

A

Hemocytoblast!

23
Q

Explain the pathway for thrombocytopoiesis

A

1) Hemocytoblast
2) myeloid stem cell
3) Megakaryocyte
* Fragmentation
4) Platelet!

24
Q

Explain the pathway for granulated leukopoiesis

A

1) Hemocytoblast
2) myeloid stem cell
3) Blast cells (committed cells)
4) progranulocyte
5) 3 different myelocytes
6) 3 different band cells
7) Basophil, eosinophil, neutrophil

25
Q

Explain the pathway for monocyte leukopoiesis

A

1) Hemocytoblast
2) myeloid stem cell
3) myleoblast ** different from the granulated
4) Monocyte

26
Q

Explain the pathway of erythropoiesis

A

1) Hemocytoblast
2) Myeloid stem cell
3) Proerythroblast
4) erythroblast
Phase 1: ribosome synthesis
Phase 2: hb synthesis
5) Normoblast
phase 3: nucleus ejected
6) Reticulocyte
(Young erythrocyte in circulation)
7) Erythrocyte

27
Q

Explain leukopoiesis of lymphocytes

A

1) Hemocytoblast
2) lymphoid stem cell
3) Lymphoblast
4) Lymphocyte (T or B)

28
Q

During hb recycling in liver & Spleen: what is the globin broken down into

A

Amino acid - it then enters circulation

29
Q

During hb recycling in liver & Spleen: what is the heme first broken down into

A

1) Biliverdin (green)

2) iron

30
Q

During hb recycling in liver & Spleen: what happens to the iron?

A

1) it is bound to transferrin for transport in blood

2) It is taken to either the liver + spleen again or bone marrow

31
Q

During hb recycling in liver & Spleen: what happens to the iron in the liver/ spleen

A

Stored as ferritin & hemosiderin

32
Q

During hb recycling in liver & Spleen: what happens to the iron that goes into bone marrow

A

it is used in erythropoiesis

33
Q

During hb recycling in liver & Spleen: what happens to the billiverdin?

A

it becomes bilirubin (yellow)

34
Q

how is bilirubin transported

A

conjugated to protein albumin

35
Q

what is bilirubin

A

part of bile, made by liver and put into small intestine to help break down food

36
Q

During hb recycling in liver & Spleen: what happens to the bile?

A

it is metabolized by bacteria in the lrg intestine and

37
Q

During hb recycling in liver & Spleen: what does the bile break down into

A

Urobilins & sterocobilins

38
Q

What color are urobilins

A

yellow

39
Q

what color are sterocobilins

A

brown

40
Q

which is found in urine

A

just urobillins

41
Q

which is found in stool

A

urobilins and stercobilins

Bio 153 midterm lecture (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions