Hematopoiesis

Question 1

Hematopoiesis occurs in what 4 places in a fetus?

Answer 1

• yolk sac
• liver
• spleen
• bone marrow

Question 2

From birth to age __, hematopoiesis occurs in all marrow cavities

Answer 2

4

Question 3

After age __, the bone marrow outgrows the need for hematopoiesis

Answer 3

4

Question 4

Where does hematopoiesis occur in adults?

Answer 4

Axial skeleton and proximal long bones

Question 5

3 essential components of hematopoiesis

Answer 5

• stem cells
• stroma
• growth factors

Question 6

Non-lineage specific growth factors that act on pluripotent and multipotent stem cells

Answer 6

IL-3 and GM-CSF

Question 7

These growth factors initiate self-renewal and differentiation of pluripotent and multipotential stem cells

Answer 7

IL-3 and GM-CSF

Question 8

These cells make up about 0.01-0.05% of the total bone marrow cells

Answer 8

Pluripotent stem cells (PPSC)

Question 9

These cells produce multipotential stem cells

Answer 9

Pluripotent stem cells

Question 10

Multipotential stem cells have the potential to differentiate into ________ or ________ cells

Answer 10

myeloid; lymphoid

Question 11

Progenitor cell that produces G-M progenitor and B-E progenitor

Answer 11

Myeloid progenitor

Question 12

Progenitor cell that produces DC, NK, pre-B and pre-T cells

Answer 12

Lymphoid progenitor

Question 13

Progenitor that produces neutrophils

Answer 13

G-M progenitor

Question 14

Progenitor that produces monocytes

Answer 14

G-M progenitor

Question 15

Progenitor that produces basophils

Answer 15

B-E progenitor

Question 16

Progenitor that produces eosinophils

Answer 16

B-E progenitor

Question 17

Progenitor that produces platelets

Answer 17

M-E progenitor

Question 18

Progenitor that produces erythrocytes

Answer 18

M-E progenitor

Question 19

Polychromatic erythrocyte is another term for ________

Answer 19

Reticulocyte

Question 20

Sequence of maturity of erythrocyte beginning with the precursor cell

Answer 20

Proerythroblast –> Basophilic erythroblast –> Polychromatic erythroblast –> Orthochromic erythroblast –> Reticulocyte –> Erythrocyte

” Pro Baseball Players Only Run Everywhere”

Question 21

What is the last cell that is capable of cell division in erythropoiesis?

Answer 21

Polychromatic erythroblast

“Players”

Question 22

Sequence of maturity of neutrophil beginning with the precursor cell

Answer 22

Myeloblast –> Promyelocyte –> myelocyte –> metamyelocyte –> band cell –> neutrophil

Question 23

What is the last cell that is capable of cell division in granulopoiesis?

Answer 23

Myelocyte

Question 24

______ mature into promonocytes and then into _______ in the blood and _______ in the tissues

Answer 24

Monoblasts; monocytes; macrophages

Question 25

Sequence of maturity of platelets beginning with the precursor cell

Answer 25

Megakaryoblast –> Promegakaryocyte –> Megakaryocyte –> Platelets

Question 26

Plasma cells make up

Answer 26

less than 3%

Question 27

_______ make up <20% of normal adult bone marrow

Answer 27

Lymphocytes

Question 28

In normal adult bone marrow there are more/less erythroid cells than myeloid cells

Answer 28

Less

Question 29

The normal adult bone marrow is composed of about what % fat cells?

Answer 29

~50%

Question 30

Where is the puncture site for a bone marrow biopsy/ aspiration?

Answer 30

Over the iliac crest

Question 31

Aspiration provides a _____ sample while biopsy provides a _____ sample

Answer 31

Liquid; solid

Question 32

Which cell type is responsible for removing abnormal or senescent RBCs?

Answer 32

Macrophages

Question 33

The ______ becomes more basophilic in normal blood cell maturation

Answer 33

Nucleus

Question 34

Megakaryocytes produces platelets from ______ and ______

Answer 34

Membranes and proteins

Question 35

CFU-GEMM includes which cell types?

Answer 35

Granulocytes, Erythrocytes, Monocytes, Megakaryocytes