Hematopoiesis Flashcards
Hematopoiesis occurs in what 4 places in a fetus?
- yolk sac
- liver
- spleen
- bone marrow
From birth to age __, hematopoiesis occurs in all marrow cavities
4
After age __, the bone marrow outgrows the need for hematopoiesis
4
Where does hematopoiesis occur in adults?
Axial skeleton and proximal long bones
3 essential components of hematopoiesis
- stem cells
- stroma
- growth factors
Non-lineage specific growth factors that act on pluripotent and multipotent stem cells
IL-3 and GM-CSF
These growth factors initiate self-renewal and differentiation of pluripotent and multipotential stem cells
IL-3 and GM-CSF
These cells make up about 0.01-0.05% of the total bone marrow cells
Pluripotent stem cells (PPSC)
These cells produce multipotential stem cells
Pluripotent stem cells
Multipotential stem cells have the potential to differentiate into ________ or ________ cells
myeloid; lymphoid
Progenitor cell that produces G-M progenitor and B-E progenitor
Myeloid progenitor
Progenitor cell that produces DC, NK, pre-B and pre-T cells
Lymphoid progenitor
Progenitor that produces neutrophils
G-M progenitor
Progenitor that produces monocytes
G-M progenitor
Progenitor that produces basophils
B-E progenitor
Progenitor that produces eosinophils
B-E progenitor
Progenitor that produces platelets
M-E progenitor
Progenitor that produces erythrocytes
M-E progenitor
Polychromatic erythrocyte is another term for ________
Reticulocyte
Sequence of maturity of erythrocyte beginning with the precursor cell
Proerythroblast –> Basophilic erythroblast –> Polychromatic erythroblast –> Orthochromic erythroblast –> Reticulocyte –> Erythrocyte
” Pro Baseball Players Only Run Everywhere”
What is the last cell that is capable of cell division in erythropoiesis?
Polychromatic erythroblast
“Players”
Sequence of maturity of neutrophil beginning with the precursor cell
Myeloblast –> Promyelocyte –> myelocyte –> metamyelocyte –> band cell –> neutrophil
What is the last cell that is capable of cell division in granulopoiesis?
Myelocyte
______ mature into promonocytes and then into _______ in the blood and _______ in the tissues
Monoblasts; monocytes; macrophages
Sequence of maturity of platelets beginning with the precursor cell
Megakaryoblast –> Promegakaryocyte –> Megakaryocyte –> Platelets
Plasma cells make up
less than 3%
_______ make up <20% of normal adult bone marrow
Lymphocytes
In normal adult bone marrow there are more/less erythroid cells than myeloid cells
Less
The normal adult bone marrow is composed of about what % fat cells?
~50%
Where is the puncture site for a bone marrow biopsy/ aspiration?
Over the iliac crest
Aspiration provides a _____ sample while biopsy provides a _____ sample
Liquid; solid
Which cell type is responsible for removing abnormal or senescent RBCs?
Macrophages
The ______ becomes more basophilic in normal blood cell maturation
Nucleus
Megakaryocytes produces platelets from ______ and ______
Membranes and proteins
CFU-GEMM includes which cell types?
Granulocytes, Erythrocytes, Monocytes, Megakaryocytes
