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IHO > Hematopoesis > Flashcards

Hematopoesis Flashcards

1
Q

Where is myeloid tissue found?

A

Medullar cavity of bone

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2
Q

Where is lymphoid tissue found?

A

thymus, LN, spleen, non-encapsulated lymph nodules

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3
Q

Where is hematopoietic tissue derived from?

A

Mesoderm

- except the thymus which is endoderm

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4
Q

What is the prenatal progression of dev of the hematopoiesis?

A 
yolk sac
liver
spleen
lymph nodes
bone marrow
thymus
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5
Q

What cell types does the yolk sac form?

A

Endothelial cells - primitive vessels

- undiff pluripotential stem cells

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6
Q

What makes up the undiff pluripotential stem cells?

A

Hematopoietic sc (HSC)
Colony forming units (CFU’s)
-HSC seed liver spleen LN and BM
- originate from mesoderm

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7
Q

When does BM take over hematopoiesis from liver?

A

Middle of fetal life

  • 5th fetal month
  • clavicle is first bone
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8
Q

What dominates during liver hematopoiesis?

A

erythropoiesis

- RBC’s nucleated at weeks 7 and un at weeks 11

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9
Q

When does hematopoiesis begin in the spleen?

A

3rd fetal month

  • erthropoiesis and granulopoiesis reach peach at 3-5 months and last till 7-8
  • lymphopoiesis continues through life
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10
Q

What is the function of the thymus?

A

Lymphopoiesis only

  • 5th fetal month
  • t-cell fromation
  • only 2-4% succeed others go to apoptosis and get phagoctyosed by macs of thrymus
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11
Q

What is extramedullar myelopoiesis?

A

development of the the myeloid tissue outside of the BM

- pathological condition

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12
Q

What is yellow marrow?

A

occupies diaphysis of long bones

  • fat and blood vessels
  • increases with age
  • thus most BM in adults is yellow
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13
Q

What is red marrow?

A

Site of hematopoiesis

  • decreases with age
  • long/short bones, iliac crest, vertebral bodies, ribs and skull diploe
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14
Q

What are the components of myeloid tissue in BM?

A

Stroma
Sinusoids
Dev blood cells

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15
Q

What cells are considered stroma?

A
  • Fibroblasts
  • macs
  • adipocytes
  • osteogenic cells (clasts and blasts)
  • endothelial cells
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16
Q

What fibers are considered stroma?

A

collagenous

reticular

17
Q

What are the purpose of sinusoids?

A

connect arterial and venous side of circulation via capillaries in bone.
- permit red and white cells to enter circulation

18
Q

What 2 ways can RBC’s and WBC’s enter our circulation?

A

Intercellular gaps

Endothelial cell pores

19
Q

What are poietins? and a common one?

A

Usually glycoproteins that act as diff and growth regulation factors
- erythropoietin

20
Q

Where is erythropoietin found and what is its function?

A

Kidney and other sites

  • increased # of hemoglobin- forming cells by stimulation stem cells (CFU-E)
  • CFU-E is the hematopoietic colony forming unit
  • induced by hypoxia
21
Q

What is the cytoplasm dev of RBC’s?

A

Basophilic then eosinophilic

- volume decreases

22
Q

What is the nucleus dev of RBC’s?

A

large to small to gone

  • light/euchromatic to dark/heterochromatic
  • fine to clumped chromatin pattern
23
Q

What are some fun facts about erythropoiesis?

A
  1. 5 mil released/sec- matched by destruction in BM and Spleen
    - 20-30% of BM cell involved in RBC’s production
    - 1 week to mature
24
Q

What is the progression of cytoplasm in ganulopoiesis?

A

basophilc to lack of it

  • increase # of specific granules
  • Decrease # in azurophilic granules
25
Q

What is the progression of the nucleus in granlopoeisis?

A

Round to polymorphonuclear

- present nuclei to gone

26
Q

How long does it take Granulocytes to mature?

A

14 days

  • 1.25 mil WBC’s released/ sec
  • in blood for 6-10 hours
  • leave vasculature and function in connective tissue
27
Q

What is the maturation of lymphocytes?

A

MLP–> lymphoblast–> pro-lymphocyte–> mature B/T/NK Cells

28
Q

What is the maturation of monocytes in monopoiesis?

A

CMP–> monoblast–> pro-monocyte–> monocyte

29
Q

Do nucleuses in thrombocytopoeisis undergo endomitosis without cytokinesis or karokinesis?

A

yes

30
Q

What is the progression and maturation of RBC’s?

A
  1. Pro-erythroblast (blast cell)
  2. Basophilic erythroblast
  3. Polychromatophilic erythroblast
  4. Orthrochromatophilic erythroblast
  5. Reticulocyte
  6. Mature erythrocyte
31
Q

What are the steps of granulopoiesis?

A
  1. Myeloblast
  2. Promyelocytes
  3. Myelocyte
  4. Metamyelocyte
  5. Band Cell
  6. Mature Leukocyte

IHO (10 decks)

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