Hematological diseases Dr. T Flashcards

1
Q

What causes Iron Deficiency anemia?

A
  • *menstruation, pregnancy, malabsorption diseases
    (eg. Celiac)**
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What causes Megaloblastic Anemias
?

A

o Folic Acid def
o Vit B12 def (pernicious anemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What causes Thalassemia & Sickle Cell anemia ?

A

Genetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What causes Aplastic Anemia ?

A

– environmental, things like bensin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What causes Anemias of Chronic Renal Insufficiency?

A

low levels of
erythropoietin – organ disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What causes Anemias of Chronic Disease?

A

inflammatory conditions, malignancy
– organ disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What causes Myelodysplastic Syndrome?

A

– environmental

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is this clinical presentation?

A

microcytic,
hypochromic anemias
(iron deficiency):

Pallor

Anemia: reduction in O2 carrying capacity
Diagnosis: RBC counts, Hg, HCT, red cell indices for dx of type of
anemia
▪ Normal upper labial mucosa

▪ Pale lower labial mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is this clinical presentation?

A

Iron deficiency anemias
Microcytic hypochromic

Atrophic glossitis – tongue has been a little denuded of papilla
Angular cheilitis – white and redness at angle of mouth/
commissure
▪ Plummer‐Vinson Syndrome: type of iron deficiency anemia
o Chronic iron def, dysphagia (esophageal webs), atrophic glossitis.

  • Significantly increased risk of esophageal cancer (SCC)
  • More commonly seen in European women
  • Have difficulty swallowing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is this clinical presentation?

A

microcytic,
hypochromic anemias
(iron deficiency):

Pallor

Anemia: reduction in O2 carrying capacity
Diagnosis: RBC counts, Hg, HCT, red cell indices for dx of type of
anemia
▪ Normal upper labial mucosa

▪ Pale lower labial mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is this clinical presentation?

A

Macrocytic
(megaloblastic)
Anemias:

▪ Folic acid and B12 deficiencies

  • Glossitis
  • Denuded dorsal surface
  • Burning, stinging pain

Seen in older patients and seen in patients with poor nutrition

Etiology: alcoholism, malabsorption, medications
(trimethoprim, oral contraceptives, anticonvulsants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is Pernicious anemia?

What causes it?

Which age and race does it most affect?

A

Pernicious – “highly injurious or deadly”
▪ Lack of intrinsic factor protein in stomach decreases absorption of
vitamin B12

Etiology is usually the body making antibodies against parietal cells which make intrinsic factor
o Autoimmune disease effecting parietal cells leads to
decreased intrinsic factor

▪ More common in elderly
▪ More common in patients of Northern European and African
decent

This anemia can lead to death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

If a patient has a Burning Tongue

What steps must we take

A

fungal (candidiasis) –> mucosal smear/ Empirically can give antifungals (to figure out if it is candidiasis can do a smear or give antifungal)
If not candidiasis order cbc
▪ Order CBC with diff
▪ Order blood levels on Fe, Folate, B12, zinc
▪ Rule out : diabetic neuropathy
If not candidiasis and blood work didn’t show anything abnormal patient has burning mouth syndrome
TIBC tests to see if theres too much or too little FE in the blood,
measures the bloods capacity to bind fe with transferrin

B12 def can be from pernicious anemia ( Schilling test for
Pernicious Anemia
) lack intrinsic factor to allow proper absorption, malnutrition or malabsorption from GI conditions can lead to this as well.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the treatment for
Deficiency Anemias

Iron def?

A

▪ Ferrous sulfate 325 mg TID between meals
o can cause Constipation
▪ add on fiber to diet, green leafy vegetables
o IV doses for absorptive problems
▪ 125mg in 100ml saline infused over 1 hour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the treatment for
Deficiency Anemias

Folic Acid def?

A

o 1mg PO, 5mg in malabsorptive disease
o Pregnant women given folic acid to decrease spina bifida
o Can be given IM injections if have malabsorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the treatment for
Deficiency Anemias

B12 def?

A
  • b 12 1mg IM injections weekly for 1‐2 months
  • Monitored for lifetime
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is Thalassemia?

A

▪ A group of disorders of hemoglobin synthesis characterized by
decreased synthesis of either the alpha‐globin or beta‐globin
chains of the hemoglobin molecule

Patients get a microcytic, hypochromic anemia
▪ People with the abnormal gene have a resistance to malaria
▪ People who have the trait rather than the disease are more likely
to live and not die from malaria and spread that gene to their
children
▪ Severity depends on the specific genetic alteration and whether it
is homozygous (severe) or heterozygous (no clinical sign to mild
manifestations)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is this clinical presentation?

A

Beta‐thalassemia

▪ Two defective genes – thalassemia major (Cooley’s anemia,
Mediterranean fever)

o Disease detected when fetal hemoglobin ceases to be
made (~3‐4 months old)
o Extramedullary hematopoiesis cause hepatosplenomegaly,
bone marrow hyperplasia, and lymphadenopathy
o In jaws, painless enlargement of maxilla and mandible
(“chipmunk” facies)
o Skull films show “hair‐on‐end” appearance
o Untreated, patient dies by about one year of age
o Treatment is repeated blood transfusions or bone marrow
transplant

this pt was treated with

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is this clinical presentation?

A

Beta‐thalassemia

▪ Two defective genes – thalassemia major (Cooley’s anemia,
Mediterranean fever)

Hyperplasia of maxilla, body is trying to make more rbc so bone
marrow enlarges to support space of those red blood cells but rbc
are abnormal so spleen keeps destroying them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What type of Alpha‐thalassemia is not compatible with life

A

When there are Four defective genes – Hb Bart’s hydrops fetalis
o Lethal in utero or within a few hours of birth
o Not compatible with life

▪ Estimated that 5% of world population carries a variant of Alpha‐thalassemia (over 100 genetic forms)

▪ One defective gene –
o no disease detected
▪ Two defective genes – alpha‐thalassemia trait
o Mild degree of anemia (usually not clinically significant)
▪ Three defective genes – Hb (hemoglobin) H disease
o Hemolytic anemia and splenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Which ares alpha thalassemia is common?

A

Areas with a lot of malaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is Polycythemia

A

▪ Increase in the number of circulating red blood cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the types Polycythemia ?

A

▪ Types

  • Primary polycythemia: polycythemia vera
  • Secondary polycythemia: response to low O2 environment such as sleep apnea, living in high elevations, smoking
  • Relative polycythemia
    • Dehydration, diuretics, vomiting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

People with chronic Polycythemia are at
increased risk of —— or ——-

A
  • *of MI or CVA (cerebral vascular accident or
    stroke) **
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What is this clinical presentation?

A

Secondary
Polycythemia

Oral manifestation

▪ Oral mucosa appears deep red
▪ Glossitis
▪ Gingiva appears edematous and bleeds easily
▪ Consequent “crowding out” of WBCs and platelets may result in
other manifestations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is Sickle Cell Anemia?

Type of inheritance

What causes it?

A

▪ Genetic disorder of hemoglobin synthesis (one of the
hemoglobinopathies)

▪ Autosomal recessive pattern

Mutation in DNA of thymine for adenine causes alteration of
codon resulting in the substitution of the amino acid valine for
glutamic acid in the beta‐globin chain of hemoglobin

▪ This transformed hemoglobin is prone to molecular aggregation
and polymerization to form a rigid and curved shape (sickle shape)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is Sickle cell crisis

What trigger it?

What are the symptoms?

effect on dental tx?

consequences?

A
  • sickling of the RBCs becomes severe
  • precipitated by such things as hypoxia, infection,
    hypothermia, or dehydration
  • Symptoms include pain (which may be severe) due to ischemia
    and infarction of affected tissues
    ▪ Long bones, lungs and abdomen are common sites of occurrence for “crises”
    ▪ Episodes last from 3‐10 days, some patients have monthly crises, some may go a year or more between
    ▪ May need pre‐medication prior to dental treatment
  • infections are the most common cause of death in sickle cell
    patients (in the US)
    ▪ Patients also have impaired kidney function and CNS involvement (strokes in 5‐8%, often prior to age of 10)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is Sickle cell crisis

treatment and how it diagnosed?

A
  • ▪ Transcranial Doppler scan used to evaluate blood flow in brain
    Hydroxyurea may be used as a therapy
    o Induces Hb F formation (doesn’t sickle)
    o But can be carcinogenic and teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Sickle Cell Anemia Types and which is resistant to malaria?

A
  • Sickle cell trait ‐ one allele is affected, only 40‐50% of hemoglobin will be abnormal, no significant clinical manifestations
  • Sickle cell disease ‐ both alleles affected, close to 100% of hemoglobin is abnormal, significant clinical problems

Abnormal gene confers resistance to malaria, therefore, sickle cell trait is seen most frequently in populations from areas endemic for malaria (Africa, the Mediterranean, and Asia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What is this radiographic presentation?

A

Sickle Cell Anemia

Radiographic findings include:

o decreased trabecular pattern in the mandible (due to
increased extramedullary hematopoiesis)

o laddering of inter‐radicular trabeculae
o “hair‐on‐end” appearance of skull films (less prominent
than with thalassemia)

Can see spontaneous pulpal necrosis in the absence of trauma or
caries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What is this clinical presentation?

A

Sickle Cell Anemia

Can see prominent trabeculae left, looks like steps on a ladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What is Aplastic Anemia?

What it is associated with?

Who are at increased risk of developing this anemia?

A

Failure of the hematopoietic precursor cells to produce adequate numbers of all types of blood components

▪ Rare, but life threatening

Associated with environmental toxins (benzene), certain drugs
(antibiotic chloramphenicol), or infection with certain viruses
(non‐A, non‐B, non‐C, non‐G hepatitis)

Fanconi’s anemia and dyskeratosis congenita patients have an
increased risk of developing this

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is this clinical presentation?

A

Aplastic Anemia

▪ Failure of the hematopoietic precursor cells to produce adequate
numbers of all types of blood components

▪ Rare, but life threatening
Associated with environmental toxins (benzene), certain drugs
(antibiotic chloramphenicol), or infection with certain viruses
(non‐A, non‐B, non‐C, non‐G hepatitis)

Fanconi’s anemia and dyskeratosis congenita patients have an
increased risk of developing this

Oral signs: are associated with the thrombocytopenia and include
spontaneous gingival hemorrhage, mucosal petechiae, purpura,
and ecchymoses
Nonspecific oral ulcerations (neutropenic ulceration) may also be seen on any mucosal surface, but especially in areas of trauma
(even minor trauma, ex. gingiva)
o Neutropenic = low neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Aplastic Anemia

treatment

A
supportive care initially, attempts to stimulate
bone marrow (androgenic steroids), and bone marrow transplants
for severe cases (prognosis is guarded at best)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is this clinical presentation?

A

Aplastic Anemia

  • One of the main differences between and neutropenic ulcer and an empthis ulcer? Is the red halo, the mucosa surroundingneutropenic ulcer Is pale and not red.
  • The center of a neutropenic ulcer has granulation tissue with a little bit of white
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is this

Hemophilia ?

What are its types

A

Bleeding disorders associated with a genetic deficiency of any
one of the clotting factors

o Hemophilia A (classic type, most common type )
▪ Factor VIII deficiency
▪ X‐linked recessive
▪ Abnormal PTT
o Hemophilia B (Christmas disease)
▪ Factor IX deficiency,
▪ X‐linked recessive, Abnormal PTT
o Von Willebrand’s disease
▪ Abnormal von Willebrand’s factor, abnormal
platelets
▪ Autosomal dominant
▪ Abnormal BT, abnormal PTT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is this clinical presentation?

A

o Hemophilia A

A patient with only 25% of normal clotting factor VIII levels may function normally, but less than 5% will likely manifest as bruising and bleeding problems

▪ Deep hemorrhage in joints is a major complication resulting in
arthritis, ankylosis and deformity

▪ Oral findings include bleeding (often uncontrolled) upon scaling and root planing, tooth extractions and any oral lacerations
▪ Pesudotumor of hemophilia
o Tissue hemorrhage can result in a submucosal tumor‐like
mass
o Bone hemorrhage can result in intraosseous radiolucency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Hemophilia A & dental treatment

A

▪ Partial thromboplastin time (PTT), prothrombin time (PT), bleeding time (BT) and platelet counts, as well as consultation with physician, should be done prior to any dental treatment
▪ (PT is like INR, Normal INR between 0.8 and 1.2)
▪ Clotting factor replacement therapy (synthetic) given as indicated
▪ Avoid aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What is THROMBOCYTOPENIA?

What causes it?

A

Markedly decreased numbers of circulating blood platelets (severe
cases < 10,000/mm³)

Etiology: Can be from:
o Decreased production (malignancy, drugs)
o Increased destruction (immunologic, drugs)
o Sequestration in the spleen (splenomegaly)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What is THROMBOCYTOPENIA?

How it presents clinically?

A

▪ Clinically see spontaneous gingival bleeding, petechiae,
ecchymosis and hematomas
o Clinically see some type of bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What is the treatment of

THROMBOCYTOPENIA?

A

▪ Treatment is usually platelet transfusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What is this clinical presentation?

A

o hematoma

because of THROMBOCYTOPENIA or Trauma

43
Q

What is this clinical presentation?

A

o hematoma

because of THROMBOCYTOPENIA orTrauma

44
Q

What is this clinical presentation?

A

Hematoma

because of THROMBOCYTOPENIA or Trauma

45
Q

What is this clinical presentation?

A

Hematoma

because of THROMBOCYTOPENIA or Trauma

46
Q

What is Cyclic Neutropenia?

What causes it

When do symptoms begin?

What problems patients deal with?

A

Cyclic Neutropenia

▪ A rare idiopathic disorder characterized by regular periodic
reductions in the neutrophil population

Etiology: Underlying cause is a defect in hematopoietic stem cells in the marrow

▪ Symptoms usually begin in childhood
▪ Most symptoms when neutrophil count is at its lowest point
(nadir), usually lasts 3‐6 days (even when neutrophil counts are at their highest, it’s often lower than normal)
▪ Patients have repeated problems with infections

Oral ulcerations on any mucosal surface exposed to minor trauma & can mimic recurrent aphthous ulcerations without the
erythematous halo that is so typical of aphthous
▪ Gingiva is most severely affected with periodontal bone loss and tooth mobility

47
Q

Cyclic Neutropenia

​length of the cycle

Symptoms

Diganosis

Treatment

A

▪ Usually a 21 day cycle

o Dx – when count falls below 500/ul for 4‐5 days every 21
days

▪ Patients experience recurrent fever, mallaise, anorexia, cervical
lymphadenopathy, oral ulcerations, etc.

▪ Treatment can be just supportive in mild cases, granulocyte
colony‐stimulating factor for more severe cases

48
Q

What is this clinical presentation?

A

Cyclic Neutropenia

Oral ulcerations on any mucosal surface exposed to minor trauma & can mimic recurrent aphthous ulcerations without the
erythematous halo that is so typical of aphthous
▪ Gingiva is most severely affected with periodontal bone loss and tooth mobility

49
Q

What is this clinical presentation?

A

Cyclic Neutropenia

▪ Oral ulcerations on any mucosal surface exposed to minor trauma (L,T, BM and oropharynx) last 5‐7 days
▪ Depending on surface involved, can mimic recurrent aphthous
ulcerations

o Usually do not see erythematous halo that is so typical of
aphthous
Gingiva is most severely affected with periodontal bone loss and tooth mobility

50
Q

What is this clinical presentation?

A

Cyclic Neutropenia

▪ Depending on surface involved, can mimic recurrent aphthous
ulcerations
o Usually do not see erythematous halo that is so typical of
aphthous

51
Q

What is this clinical presentation?

A

Cyclic Neutropenia
▪ Gingiva is most severely affected with periodontal bone loss and
tooth mobility

52
Q

What is this clinical presentation?

A

Cyclic Neutropenia

o Teeth floating in air

53
Q

o Differential diagnosis when you see this
“floating in air teeth” in children

A
  • Cyclic neutropenia
  • aggressive periodontitist
  • pamiona fav
  • burkitts lymphoma
  • langerhan cell histocytosis

o All these things can occur in children and lead bone
destructions and look like teeth are floating

54
Q

What is Agranulocytosis?

Etiology?

pts at increase risk of what?

A

Agranulocytosis

Decrease in the number of cells from the granular cell lineage
(neutrophils, eosinophils, basophils, etc.)
o Decreased production or increased destruction

▪ Some cases are idiopathic, most are drug induced
▪ Anticancer chemotherapeutics ‐ inhibit mitotic division and
maturation of hematopoietic stem cells.
▪ In rare cases, agranulocytosis is a congenital syndrome.

▪ Increase risk of infections

55
Q

What is this clinical presentation?

A

Agranulocytosis

Oral findings:

  • include multiple ragged ulcerations of the oral mucosa
  • o can mimic recurrent aphthous depending on sites involved
  • (but often no erythematous halo) – more like neutropenic ulcer
  • Gingiva is a common site due to the minor trauma caused bymastication (can resemble NUG)
56
Q

What is this clinical presentation?

A

Agranulocytosis

Oral findings:

  • include multiple ragged ulcerations of the oral mucosa
  • can mimic recurrent aphthous (but often no erythematous halo)
  • Gingiva is a common site due -can resemble NUG)
57
Q

Agranulocytosis

Symptoms

Treatment

A

Symptoms

  • ▪ Initial symptoms include non‐specific symptoms of infection malaise, sore throat, swelling, fever, chills, etc.
  • Oral findings include multiple ragged ulcerations of the oral mucosa, o can mimic recurrent aphthous but no erythematous halo, Gingiva is a common site & can resemble NUG

Treatment

  • Remove offending drug, numbers should replenish in 10‐14 days
  • Agranulocytosis secondary to cancer therapy ‐ meticulous oral hygiene, chlorhexidine rinse (non alcohol type) , etc.
58
Q

What is Leukemia?

A

▪ Represents several types of malignancies derived from
hematopoietic stem cells

▪ ~ 2.5% of all cancers in USe

59
Q

What are the Clinical signs and symptoms of Leukemia

A

▪ related to crowding out of normal hematopoietic stem cells in the bone marrow
o ↓ in normal WBC, RBC, and platelets
▪ See fatigue, bleeding, bruising, fevers and infections, etc.

60
Q

Types of leukemia

A

Divided into acute and chronic, myeloid and lymphoid
o Acute myeloid, chronic myeloid, acute lymphoid, and
chronic lymphoid
▪ Acute leukemia
o Typical course under 6 mos
o Untreated, runs an aggressive course often causing death
▪ Chronic leukemia
o 2‐6 or more years
o More indolent course, although, they too often result in
death
▪ Leukemia, like lymphoma, can cause bone destruction and the
radiographic appearance of “teeth floating in air” in children

61
Q

which leukemia always in children?

A

Acute lymphoblastic leukemia (ALL)

Success in treatment of a previously fatal disease

Children age 1‐10 years have higher success with
treatments than teenager do (10‐20yrs)
o And infants (under 1yr) do the worst

Chemotherapy that are given for curing ALL actaully
causes problems when they are older.

62
Q

which leukemia in eldery and most common?

A

Chronic lymphocytic leukemia

o Elderly
o Most common type
o Considered incurable at this time
o unchecked proliferation of B‐cells
o no good treatment

63
Q

AML in which age group is found and

which leukemia has peak in 3rd to 5th decade?

A
**▪ Acute myeloid leukemia**
o Adult (and children)

▪ Chronic myeloid leukemia
o Peak 3rd ‐ 5th decade

64
Q

etiology of leukemia

A
  • Probably caused by a combination of environmental and genetic factors
  • Some leukemias have specific genetic alterations (ex. CML –
  • Philadelphia chromosome)
    • Translocation of 9 and 22 and fusion gene BCRABL1
  • Environmental factors include:
    • ionizing radiation
    • pesticides
    • benzene
    • viruses (ex. HTLV‐1)
65
Q

What is this clinical presentation?

A

Leukemia

Acute and chronic myelo‐monocytic leukemia are the most likely
types of leukemia to exhibit oral manifestations
o Generalized gingival hypertrophy

May create a tumor‐like mass in soft tissue
o granulocytic sarcoma/chloroma (clinically looks green)
▪ mass infiltrate into soft tissue

66
Q

What is this clinical presentation?

A
67
Q

What is this clinical presentation?

A

Leukemia

▪ Oral findings include gingival hyperplasia, spontaneous bleeding of gingiva, mucosal ulcerations, candidiasis, recurrent herpetic lesions, etc.
▪ Leukemic infiltrate in soft tissues (ex. gingiva) produces a diffuse,
boggy, nontender swelling that may or may not ulcerate
o most common with myelo‐monocytic types
▪ May create a tumor‐like mass in soft tissue
o granulocytic sarcoma/chloroma (clinically looks green)
▪ mass infiltrate into soft tissue

If you see children and notice they have prominent areas
of redness or red/purple and know the child has decent
oral hygiene, leukemia should be in your differential. Need
to be aware of that cause patients need to be treated in a
fairly quick fashion.

68
Q

What is this clinical presentation?

A

Leukomia

o Leukemic infiltrate – have areas of erthema
o Looks like gingival hyperplasia, but in gingivail hyperplasia
you don’t have the same amount of redness. Leukemia has significant hyprotophy of gingivial papilla and areas that look like they have ptechia in them. With gingival
hyperplasia drug induced they are very fibrotic

69
Q

What is this clinical presentation?

A

Leukemia

o Dilantin hyperplasia (drug induced gingival hyperplasia) –
fibrotic looking

o Has to an addition of thromocytopenia

70
Q

What is this clinical presentation?

A

Leukemia

This is Chloroma, inflitrate gets so dense they look green. On
buccal or lingual mucosa chloroma are more of a
solitary mass, gingival it more diffuses

71
Q

What is this clinical presentation?

A

leukomia

Cause of infiltrate they has bone loss

72
Q

What is this clinical presentation?

A

leukomia

o Multifocal bony destruction
o Widened PDL with leukemic infiltrate

▪ Symmetric widening of PDL space in a patient that doesn’t have that normal vertical bone loss that you associate with periodontal
disease.
▪ If see symmetrical bone loss in PDL space think malignancy, neoplastic
● Lymphomas, leukemias, osteocarcoma, chondro scaroma can
do this

73
Q

What is this clinical presentation?

A

Adult acute myeloid leukemia (AML)

is a type of cancer in which the bone marrow makes a large number of abnormal blood cells.

We see in these images:
o Hemorrhagic ulcer right vestibule

o Ulcers are deep and can go down to bone

o Ulcers resolved after treatment

74
Q

What is the treatment of Leukemia?

A
  • Treatment depends on specific type of leukemia, but includes multi‐agent chemotherapy (often an initial high dose induction and then a lower maintenance dose)
    • And for lymphoma
  • Bone marrow transplant has been used with limited success
75
Q

What is this clinical presentation?

A

Non‐Hodgkins Lymphoma (NHL)

o The most common of the lymphoproliferative diseases
o Uncontrolled proliferation of B or T cell origin derived
from a single cell (or clone)
o Typically presents with painless lymphadenopathy
(often unilateral)
▪ up to 40% are extranodal
▪ 5‐10% arise in Waldeyer’s ring

76
Q

What is this clinical presentation?

A

Non‐Hodgkins Lymphoma (NHL)

o The most common of the lymphoproliferative diseases
o Uncontrolled proliferation of B or T cell origin derived
from a single cell (or clone)
o Typically presents with painless lymphadenopathy
(often unilateral)
▪ up to 40% are extranodal
▪ 5‐10% arise in Waldeyer’s ring

77
Q

What is this clinical presentation?

A

Non‐Hodgkins Lymphoma (NHL)

o Typically presents with painless lymphadenopathy
(often unilateral)
▪ up to 40% are extranodal
▪ 5‐10% arise in Waldeyer’s ring

Inflamatory or reactive enlarged lymph nodes tend to be

  • *soft, tender, and movable**
  • *▪** Lymph nodes associated with malignancy tend to be
  • *hard/firm, fixed, and non‐tender**
78
Q

What are the Lymphoma
Classifications?\

A
  • Low grade B cell (disseminated but slow growing)
    • Small lymphocytic, Mantle cell, Marginal zone
    • Follicular center (35‐40 % of all B cell lymphomas)
  • Moderate (aggressive)
    • Diffuse B‐cell, Peripheral T‐cell
  • High Grade B cell (disseminated and rapidly progressive)
    • Anaplastic large cell, lymphoblastic
    • Large cell (25‐30 % of all B cell lymphomas)
    • Burkitt’s
    • Immunoblastic (increasingly seen in AIDS)
      • As AIDS patients live longer we see this more
  • T cell lymphoma (less common than B cell, associated with palatal perforation [midline lethal granuloma]) (in differntial with deep fungal infections/candidiasis, TB, use of cocaine
    • Precursor T‐lymphoblastic, T cell chronic lymphocytic,
  • Hodgkin’s (bimodal ‐ late twenties and after 50 years old)
79
Q

What is this clinical presentation?

A

Burkitt’s Lymphoma

African type (endemic)

  • More common
  • Peak incidence 3‐8 years of age
  • Twice as common in males
  • ~95% associated with the Epstein‐Barr virus
  • North american or non edemic type is not associated
  • with EBV
  • ~88% under 3 yrs of age have jaw lesions
    • Only 25% of those older than 15 do
  • Typically involves:
    • MD, MX, (often affects all 4 quadrants)
    • Mandible or maxilla
    • Abdomen
  • grow quickly
80
Q

What is this clinical/radiographic presentation?

A

Burkitt’s Lymphoma

  • North American type (sporadic)
    • Typically older children (mean of 11 years)
    • Involves abdomen as a mass
    • uncommon in the jaws
    • No association with EBV
    • More localized disease
  • HIV type
    • Adults
    • 25% associated with EBV
    • GI, marrow and CNS

Teeth floating as shown in the image

81
Q

What is this clinical presentation?

A

Burkitt’s Lymphoma

Scattered throughout the lymphocytes are
macrophages containing nuclear debris (tingible body
macrophages)
o Creates a “starry sky” appearance

82
Q

What is this clinical presentation?

A

T cell Lymphoma

Less common than B cell lymphomas
▪ One variant associated with palatal perforation
o Old name midline lethal granuloma

83
Q

o Palatal perforations differerntial diagnosis

A
  • Midline lethal granuloma (T cell Lymphoma)
  • deep fungal
  • malignancy
  • TB
  • tertiary syphilis gumma,
  • cocaine abuse (necrotizing sialometaplasia‐ soft
  • tissue)
84
Q

What is this clinical presentation?

A

Hodgkin Lymphoma

▪ Cell of origin is unknown
▪ Often begins as a unifocal disease above diaphragm and then
spreads to other sites
▪ Present with painless cervical lymphadenopathy in 60‐80% of
cases

Bimodal ‐ late twenties and after 50 years old

▪ In North America and Europe, EBV positivity has been noted
in over 50 percent of mixed cellularity cases and 10 to 50
percent of nodular sclerosis cases

85
Q

What is this clinical presentation?

A

Hodgkin Lymphoma

o Begins in lymph nodes
o 70‐75% cervical/supraclavicular
o Painless but unresolving,

o Night fevers/sweats

86
Q

What is this clinical presentation?

A

Hodgkins lymphoma

87
Q

What are the Stages of o Hodgkins lymphoma

A

▪ Stage I and II – localized disease curable with RT
▪ Stage III and IV – more widespread and treated with chemo
and RT, worse prognosis
▪ Stage determined by sites involved
o Above diaphragm – stage 1 and 2
o Above and Below diaphragm – stage 3 and 4

having it above diaphragm is bette than having it below so stage 1 and 2 are better than stage 3 and 4

88
Q

What is this histological presentation?

A

Plasma Cell Disorders

Clock face nucleaus

89
Q

What is this clinical presentation?

A

Plasma cell gingivitis

▪ Allergen causes mass infiltrate into gingival
▪ Benign
▪ Diet log to identify allergen, allergy testing

90
Q

What is this clinical presentation?

A

Plasma cell gingivitis

▪ Allergen causes mass infiltrate into gingival
▪ Benign

91
Q

Plasma cell gingivitis Treatment

A

▪ Diet log to identify allergen, allergy testing
▪ Ideally eliminate offending substance
Can manage with topical steroids

92
Q

What is this clinical presentation?

A

Multiple Myeloma

Monoclonal expansion of malignant plasma cell
▪ Most common in 40‐70 year old (mean 63 yo.)
▪ Present with bone pain (> 70%) and pathologic fractures

Punched out radilucency

93
Q

What are the Clinical and radiological features

of

Multple Myeloma MM

A

Bones most commonly involved include ribs, vertebrae and
skull

o 70‐90% will have jaw involvement at some point
Anemia, thrombocytopenia and neutropenia due to
crowding out of normal cells within bone marrow by
proliferating malignant cells
50‐60% have Bence‐Jones proteins in urine (light chains,
usually kappa)
o Due increased plasma cells ⇒ plasma cells make
antibodies ⇒ antibodies/proteins gets excreted

Solitary plasmacytoma can be the first sign of multiple
myeloma

▪ Radiographically, see punched out radiolucencies (no
sclerotic margin) often with an irregular outline

94
Q

What is this clinical presentation?

A

Multiple Myloma

Punched out translucency in crest

95
Q

What is this clinical presentation?

A

Multiple myeloma

96
Q

What is this clinical presentation?

A

Multiple Myeloma

97
Q

What is this clinical presentation?

A

Multiple Myeloma

Pathological fracture

98
Q

What is this clinical presentation?

A

Multiple Myeloma

Elevated M spike in serum ‐ abnormal increase in
immunoglobulin (hyperglobulinemia), most commonly IgG
▪ Reversal of normal albumin/globulin ratio

99
Q

How is Multiple Myeloma treated?

Prognosis?

A
  • Chemotherapy with or without RT
  • Bone marrow transplant, interferon, antibodies made
  • against tumor cells, thalidomide, bisphosphonates,
  • corticosteroids, melphalan, etc.
  • Even with treatment, most patients do not survive more than
  • 18‐24 months
    • older patients – better prognosis
    • younger patients – more aggressive and worse prognosis
  • IV bisphosphonate therapy puts patients at increase risk for MRONJ
100
Q

What is this clinical finding?

A

Multiple Myeloma

Deposition of amyloid in soft tissues
o Can cause macroglossia if tongue is involved

101
Q

What is this radiographical presentation?

A

Plasmacytoma

▪ Unifocal, monoclonal neoplastic
▪ proliferation of plasma cells

▪ 30% develop into MM over 10 yrs
▪ 50% disseminate w/in 2‐3 yrs
▪ Central Bone lesion
o Unilocular radiolucency
o Swelling or bone pain
o Non‐tender soft tissue mass

▪ 90% occur in Head and neck

102
Q

What is the prognosis of Plasmacytoma

and how it is treated?

A

▪ Tx: radiation, better prognosis than MM

▪ Solitary better prognosis than disseminated MM

103
Q

What is Neoplasias?

A
  • Immune cell tumors primarily involving bone marrow and peripheral blood are classified as leukemias
  • while those of lymph nodes are classified as lymphomas,
  • however there is often overlap of these entities