Hematologic Patho I

Question 1

What are the 2 different lineages that stem cells can go down

Answer 1

• common myeloid progenitor

- Common lymphoid progenitor

Question 2

when does bone marrow production increase

Answer 2

With acute inflammation associated w pyogenic bacterial infection or tissue necrosis

larg shift în neutrophil count = Bacterial infection

Question 3

What is increased eosinophils seen in

Answer 3

• aergies/asthma
• parasites
• drugs
• certain skin diseases and canceers

Question 4

When will you see increased monocytes generally

Answer 4

certain chronic diseases such as collagen vascular diseases and IBD

Question 5

when will you see increased lymphocytes

Answer 5

–acute viral diseass
chronic inflammatory processes
Infectiosios mono

Question 6

pathology of mono

Answer 6

• EBV invades B lymphocytes via CD21 receptors

- cytotoxic t lymphocytes respond against invaded B cells and form atypical lymphocytes

Question 7

What is the antibody production in mono and what is it the basis of

Answer 7

Heterophil antibodies are the basis of the paul bunnel reaction (mono spot test)

Question 8

Classic triad of mono

Answer 8

-fever
-sore throat
-Lymphadenitis (post auricular nodes)
(4th sign- heptosplenomegaly)

Question 9

What is leukopenia

Answer 9

Decreased number of neutrophils in peripheral blood

Question 10

What can leukopenia happen

Answer 10

Decreased production (aplastic anemia/chemo)
Increased destruction (Inf, Autoimmune)
Septic shock (activation of neutrophil adhesion molecules on endothelium)

Question 11

What is decreased eosinophils usually associated w

Answer 11

-usually associated w increased cortisol (bushings, exogenous corticosteroids)

Question 12

What is lymphocytopenia (decreased lymphocytes) typically due to

Answer 12

Associated w conditions when lymphocytes are destroyed as result of viral infection or congenital condition

(immunodeficiency syndromes, SLE, corticosteroids, radiation (VERY SENSITIVE TO IT))

Question 13

what is lymphadenopathy

Answer 13

Lymph node enlargement due to reactive conditions (bac inf/autoimmune) or neoplasia

Question 14

What is acute non specific lymphadenitis due to

Answer 14

Due to presence of foreign body or infection

tender enlargement of lymph nodes

Question 15

What is chronic non specific lymphadenitis and what is it seen in

Answer 15

Non tender enlargement of lymph nodes

Follicular hyperplasia involves B lymphocytes and may be seen w rheumatoid arthritis, toxoplasmosis and early HIV