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mls 3H > Hema 2 Lec M1.2 > Flashcards

Hema 2 Lec M1.2 Flashcards

1
Q

In the FAB Classification of AML, what type of AML is related to Disseminated Intravascular Coagulation?

A

M3

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2
Q

In FAB classification of AML, what classification does granules starts to appear?

A

M1

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3
Q

Other name for Polycythemia Vera?

A

Osler’s Disease

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4
Q

What mutation is usually present in 3% of patients with osler’s disease?

A

JAK2 Exon 12

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5
Q

Essential Thrombocythemia is also known as ____

A

Idiopathic thrombocytosis, hemorrhagic thrombocythemia, & Primary thrombocytosis

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6
Q

Term for Hematopoietic Stem Cell transplantation where your donor is from your identical twin.

A

Syngeneic

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7
Q

In malignant leukocyte disorders, what type of malignant cell is more common?

A

Lymphoma or sarcoma

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8
Q

Blast cells or immature cells are the predominant cell type in this Leukemia (Acute or Chronic)

A

Acute Leukemia

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9
Q

True or False

Presence of blast in the PBS is common

A

FALSE

Sa bone marrow lang siya makikita

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10
Q

What is the expected LAP Score of a patient suffering from Chronic Myelogenous Leukemia?

A

< 15 LAP Score

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11
Q

Philadelphia Chromosome is usually detected in this kind of leukemia

A

Chronic Myelogenous Leukemia

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12
Q

Chronic Myelogenous Leukemia usually has a mutation or translocarion between ___

A

t(9:22)(q34;q11) or BCR-ABL

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13
Q

From BM, systemic - Myeloproliferative disorders

A

Leukemia

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14
Q

From lymphoid tissue, localized- lymphoproliferative disorders

A

Lymphoma or Sarcoma

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15
Q

Myeloproliferative disorders involves CFU-GEMM which are

A

Granulocytes
Erythrocytes
Monocytes
Macrophage

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16
Q

What interleukin is involved in lymphoproliferative disorders?

A

IL-7

17
Q

Give me the 4 etiology of Leukemia

A

-Genetic Susceptibility
-Viral Infection
-Somatic Mutation
-Immunologic Dysfunction

18
Q

Predominant cell type of Acute Leukemia

A

Precursor Cell (Immature) or Blast

19
Q

Predominant cell type of Chronic Leukemia

A

Mature

20
Q

WBC Count of Acute Leukemia

A

Variable

21
Q

WBC count of Chronic Leukemia

A

Increased

22
Q

what is the difference of the progression without treatment between acute leukemia and chronic leukemia?

A

Acute leukemia is rapid progression (weeks to months) while chronic leukemia is slower (months to years)

23
Q

4 Laboratory diagnosis of Neoplasm

A

-Cytochemical Analysis
-Immunologic analysis
-Chromosomal or genetic analysis
-DNA analytical assay

24
Q

What is the chemical stain result of Acute Myeloid Leukemia with Myeloperoxidase and Sudan Black B

A

Positive

25
Q

What is the chemical stain result of Acute Lymphocytic Leukemia with Myeloperoxidase and Sudan Black B

A

Negative

26
Q

True or False
L1 & L2 of ALL are positive to TDT and negative or PAS

A

True

27
Q

General Categories of therapy for Hematologic Neoplasms

A

-Chemotherapy
-Radiation Therapy
-Supportive Therapy
-Targeted Therapy
-Hematopoietic Stem Cell Transplantation

28
Q

The Main glycoprotein hormone for RBC

A

Erythropoietin (EPO)

29
Q

Hematopoietic stem cell transplantation in other living species

A

Syngeneic

30
Q

Hematopoietic stem cell transplantation in same species

A

Allogeneic

31
Q

Hematopoietic stem cell transplantation in identical twin donor

A

Autologous

32
Q

Criterion for diagnosis of AML is the presence of 30% blasts

A

French-American-British (FAB)

33
Q

Criterion AML is the presence of 20% blasts and is more specific

A

World Health Organization (WHO)

34
Q

This refers to all myeloid cells are increased

A

Panmyelosis

35
Q

Results in increased apoptosis and has ineffective hematopoiesis

A

Myelodysplastic Sydnromes

mls 3H (12 decks)

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