Hema 2 Lec M1.2 Flashcards
In the FAB Classification of AML, what type of AML is related to Disseminated Intravascular Coagulation?
M3
In FAB classification of AML, what classification does granules starts to appear?
M1
Other name for Polycythemia Vera?
Osler’s Disease
What mutation is usually present in 3% of patients with osler’s disease?
JAK2 Exon 12
Essential Thrombocythemia is also known as ____
Idiopathic thrombocytosis, hemorrhagic thrombocythemia, & Primary thrombocytosis
Term for Hematopoietic Stem Cell transplantation where your donor is from your identical twin.
Syngeneic
In malignant leukocyte disorders, what type of malignant cell is more common?
Lymphoma or sarcoma
Blast cells or immature cells are the predominant cell type in this Leukemia (Acute or Chronic)
Acute Leukemia
True or False
Presence of blast in the PBS is common
FALSE
Sa bone marrow lang siya makikita
What is the expected LAP Score of a patient suffering from Chronic Myelogenous Leukemia?
< 15 LAP Score
Philadelphia Chromosome is usually detected in this kind of leukemia
Chronic Myelogenous Leukemia
Chronic Myelogenous Leukemia usually has a mutation or translocarion between ___
t(9:22)(q34;q11) or BCR-ABL
From BM, systemic - Myeloproliferative disorders
Leukemia
From lymphoid tissue, localized- lymphoproliferative disorders
Lymphoma or Sarcoma
Myeloproliferative disorders involves CFU-GEMM which are
Granulocytes
Erythrocytes
Monocytes
Macrophage
What interleukin is involved in lymphoproliferative disorders?
IL-7
Give me the 4 etiology of Leukemia
-Genetic Susceptibility
-Viral Infection
-Somatic Mutation
-Immunologic Dysfunction
Predominant cell type of Acute Leukemia
Precursor Cell (Immature) or Blast
Predominant cell type of Chronic Leukemia
Mature
WBC Count of Acute Leukemia
Variable
WBC count of Chronic Leukemia
Increased
what is the difference of the progression without treatment between acute leukemia and chronic leukemia?
Acute leukemia is rapid progression (weeks to months) while chronic leukemia is slower (months to years)
4 Laboratory diagnosis of Neoplasm
-Cytochemical Analysis
-Immunologic analysis
-Chromosomal or genetic analysis
-DNA analytical assay
What is the chemical stain result of Acute Myeloid Leukemia with Myeloperoxidase and Sudan Black B
Positive
What is the chemical stain result of Acute Lymphocytic Leukemia with Myeloperoxidase and Sudan Black B
Negative
True or False
L1 & L2 of ALL are positive to TDT and negative or PAS
True
General Categories of therapy for Hematologic Neoplasms
-Chemotherapy
-Radiation Therapy
-Supportive Therapy
-Targeted Therapy
-Hematopoietic Stem Cell Transplantation
The Main glycoprotein hormone for RBC
Erythropoietin (EPO)
Hematopoietic stem cell transplantation in other living species
Syngeneic
Hematopoietic stem cell transplantation in same species
Allogeneic
Hematopoietic stem cell transplantation in identical twin donor
Autologous
Criterion for diagnosis of AML is the presence of 30% blasts
French-American-British (FAB)
Criterion AML is the presence of 20% blasts and is more specific
World Health Organization (WHO)
This refers to all myeloid cells are increased
Panmyelosis
Results in increased apoptosis and has ineffective hematopoiesis
Myelodysplastic Sydnromes
