Helminthic GI (lec 8) Flashcards

1
Q

Nematode (roundworm) morphology?

A

elongated, tapering cylinder,
multiple layers of cuticle,
separate sexes

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2
Q

Nematode Life Cycle?

A

Eggs in environment
Larvae enviro to host
Adult in host

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3
Q

E. vermicularis (pinworms) epidemiology?

A

Most common helm dz in US,
P-to-P or environment
(U) kids

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4
Q

E. vermicularis infection causes?

sxs?

A

enterobiasis

(U) asymp
anal itching
(P) 2º bacterial infection

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5
Q

E. vermicularis Life Cycle?

A

1) Eggs deposited on perianal (infectious w/i 4 hrs)
2) Eggs ingested and hatch in SI
3) Mature/colonize ~ 2mo
4) GRAVID female deposits eggs on anus at night

Eggs in environment survive 2-3 wks

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6
Q

E. vermicularis diagnostics?

A

anal eggs

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7
Q

E. vermicularis tx?

A

DOC: Mebendazole or Albendazole

*treat whole family

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8
Q

Ascaris lumbricoides morph?

A

Largest intestinal worm in humans

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9
Q

A. lumbricoides epidemiology?

A

Soil transmission,

(C) warm climates

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10
Q

A. lumbricoides Life Cycle?

A

1) Eggs ingested -> larva released into duo
2) Larva penetrate mucosa -> blood into lungs
3) Alveoli -> trachea -> orophary
4) Swallowed beck to duo -> mature

Adults live 2 yrs

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11
Q

A. lumbricoides causes?

sxs?

A

Ascariasis

Asymp - blockage
depends on # of worms
(P) Pulmonary-Leoffler’s synd

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12
Q

A. lumbricoides diagnostics?

Tx?

A

Eggs in stool

DOC: Mebendazole or Albendazole

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13
Q

Trichuris trichiura (whipworm) morph?

A

small, whiptail

egg capsules

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14
Q

T. trichiura Life Cycle?

A

1) Embryonated eggs ingested
2) Larvae released in duo
3) Mature in colon
4) Released eggs can mature in soil

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15
Q

T. trichiura epidemiology?

A

Soil transmission

(U) kids

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16
Q

T. trichiura causes?

sxs/

A

trichuriasis

dependent on worm burden
aysmp to painful watery stool w/ mucus/blood
(P) rectal prolapse

17
Q

T. trichiura diagnostics?

Tx?

A

Eggs in stool

DOC: Mebendazole or Albendazole

18
Q

Necator americanus/Ancylostoma duodenale

(hookworms) Life Cycle?

A

1) Infective eggs in soil
2) Larvae penetrate skin -> blood into lungs
3) Alveoli -> trachea -> orophary
4) Swallowed beck to duo -> mature
5) Feeds on blood in mucosa

19
Q

N. americanus

A. duodenale epidemiology?

A

Human feces in soil

20
Q

N. americanus

A. duodenale sxs?

A

Depends on worm burden and host’s nutrition

Blood-filled, pruritic lesions at penetration site,
Constant blood loss from GI

21
Q

N. americanus
A. duodenale diagnostics?

Tx?

A

Eggs in stool

DOC: Mebendazole

22
Q
Strongyloides stercoralis (threadworm)
Life Cycle?
A

Two Cycles:
1) Same as hookworm -> larvae into feces

2) Multiply in soil

23
Q

S. stercoralis epidemiology?

A

Human feces in soil

(U) tropical

24
Q

S. stercoralis causes?

sxs?

A

Dep on worm burden

Visible trail under skin,
Painful D or constipation,
Life-threatening if defective cell-mediated immunity,
Can auto-reinfect for yrs

25
Q

S. stercoralis diagnostics?

Tx?

A

Larvae in stool or sputum

DOC: Thiabendazole

26
Q

Trematodes (flukes) morph?

A

flat, leaf-like w/ suckers

27
Q

Clonorchis sinensis (chinese liver fluke) Life Cycle?

A

1) Ingest encysted larvae
2) Excystation in duo
3) Mature in bile ducts
4) Eggs -> poop

28
Q

C. sinensis epidemiology?

A

Poorly cooked fish

(C) far east

29
Q

C. sinensis causes?

sxs?

A

Clonorchoriasis

(U) asymp

30
Q

C. sinensis diagnostics?

tx?

A

eggs in stool

DOC: Praziquentel

31
Q

Taenia (tapeworms) morph?

Hosts?

A

meters long
scolex (suckers/hooks)

Humans

32
Q

T. solium (pork)
T. saginata (beef)
Life Cycle?

A

1) Eggs ingested by cows/pigs
2) Hatch in duo -> penetrate wall
3) Cysticerci grow in mm

Humans eat meat:

1) Cysticerci matures in jejun
2) Eggs (proglottids) -> poop

33
Q

T. solium (pork)
T. saginata (beef) cause?

sxs?

A

taeniasis
t. solium also causes cysticercosis

(U) asymp and one worm

cysticercosis (P) lead to blindness, seizures

34
Q

T. solium (pork)
T. saginata (beef) diagnostics?

Tx?

A

Eggs/proglottis in stool
CT
Histo

DOC: Praziquantel

35
Q

Diphyllobothrium latum (fish tapeworm) Life Cycle?

A

1) Eggs hatch in fresh water
* series of host passages until
2) Larvae ingested by fish

Humans/mammals eat fish:

1) Ingest larvae -> duo
2) Adults in jeju
3) Eggs pooped

36
Q

D. latum causes?

sxs?

A

diphyllobothriasis

(U) asymp
competes for B12

37
Q

D. latum diagnostics?

Tx?

A

Eggs in stool
Anemia + hx of raw fish

DOC: Praziquantel