Diarr Protozoans (lec 7) Flashcards

1
Q

Giardia lamblia microbe characteristics?

A

flagellate protoza

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2
Q

G. lamblia morphology stages? (2)

A

1) Trophozoite:
In SI, eats mucus, Ø tissue invasion

2) Cyst:
In environment, makes 2 trophozoite, 4 nuclei when mature

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3
Q

G. lamblia Life Cycle? (4 steps)

A

1) Ingestion (infection)
2) Excystation in stomach
3) Replicate in SI bile salt and neutral pH
4) Cysts -> poop

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4
Q

G. lamblia sxs?

A

aysmp to acute/chronic D

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5
Q

G. lamblia action?

A

causes malabsorption

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6
Q

G. lamblia epidemiology?

A

highly contagious,
contaminated H2O,
(U) kids,
travel, camp, oral

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7
Q

G. lamblia diagnostics? (2)

A

Stool sample

ELISA for GSA65 antigen

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8
Q

G. lamblia tx?

A

DOC: metronidazole

Human milk has IgA against,
Develop post-exposure Ab

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9
Q

Amebiasis/

E. histolytica morph stages?

A

1) Trophozoite:
invasive/pathogenic/motile
pseudopod-forming

2) Cyst:
infectious stage

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10
Q

E. histolytica sxs?

A

Widespread (intestinal/extraintest)
asymp to colitis, abscess, ulcers

(U) bloody D

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11
Q

E. histolytica epidemiology?

A

Fecal H2O
reportable
kids, compromised

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12
Q

E. histolytica Life Cycle?

A

1) Ingest cysts
2) Excystation in Colon
3) Trophoz colonize colon mucus
4) Encyst -> poop or disseminate to blood

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13
Q

E. histolytica diagnostics?

A

stool sample
ELISA
radiology for extraintest

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14
Q

E. histolytica tx?

A

DOC: metronidazole + iodoquinol

Must boil H2O -> resistant to Cl-

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15
Q

E. histolytica virulence factors? (4)

A

1) Lectin: adhesion
2) Phospholipases: disrupt host membrane
3) Amebapore: makes channels in host (lysis)
4) Cysteine Proteases: degrade mucus, Ab, complement, cell matrix

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16
Q

Cryptospororidiosis/
C. homins
C. parvum
morphology?

A

1) Oocysts (infectious, only need 10):
ea makes 4 sporoz

2) Sporoziotes:
bind intestine epi cells

17
Q

C. homins/C. parvum sxs?

A

Watery D w/ severe wasting
5-10 days
shed for wks

18
Q

C. homins/C. parvum epidemiology?

A

C. homins - human host
C. parvum - human and bovine hosts

Endemic: P-to-P (fecal-oral)
Sporadic: cow H2O, pools (Cl- resist)

(U) kids, AIDS/compromised

19
Q

C. homins/C. parvum diagnostics?

A

Oo in stool
Immunofluo
ELISA

20
Q

C. homins/C. parvum Life Cycle?

A

1) Ingest Oo
2) Releases 4 sporo
3) Bind epi cells
4) Ingested into vacuole (separate from cytoplasm)
5) Sex rep -> thick-walled Oo -> shed
Asex -> thin-walled Oo -> reinfect host
NO MULTIPL OUTSIDE HOST

21
Q

C. homins/C. parvum tx?

A

DOC: Nitazoxanide or Paroromycin

poor prog is compromised

22
Q

Cylcosporiasis/

C. cayetanensis morph?

A

large, autofluo Oocysts

23
Q

C. cayetanensis Life Cycle?

A

Ingest Oo
same progression

Oo MUST sporulate in environment

24
Q

C. cayetanensis sxs?

A

Explosive, watery D + viral sxs

25
Q

C. cayetanensis epidemiology?

A

(U) latin america

Contaminated H2O, fruit/veg

26
Q

C. cayetanensis diagnostics?

A

Large Oo in stool

Acid-fast fluor Oo

27
Q

C. cayetanensis tx?

A

DOC: Trimeth-Sulfameth

28
Q

Blastocystis hominis morph?

A

Large central vacuole,

multiple nuclei around rim

29
Q

B. hominis epidemiology?

A

animal fecal H2O

30
Q

B. hominis tx?

A

Metronidazole

31
Q

Balantidium coli morph?

A

Large Trophozoites w/ cilia and MACROnucleus

and Cysts

32
Q

B. coli epidemiology?

A

Pig poop

33
Q

B. coli tx?

A

TCN or Metronidazole