Bacterial GI I (lec 5)

Question 1

Cholera toxin?

Answer 1

vibrio cholerae

toxin = choleragen

Question 2

Cholera action in body?

Answer 2

colonize small int mucosa

NO change in physical integrity

Question 3

Cholera presentation?

Answer 3

Abrupt onset of acute/massive “rice water” D ->
rapid depletion ->
hypovol shock, metabolic acidosis

Question 4

Cholera source?

Answer 4

Water/food,

Asymp carrier

Question 5

Cholera toxin also present in what bacteria?

Answer 5

e. coli

causes “traveler’s D”

Question 6

Vibrio cholerae characteristics?

Answer 6

G-
nonspore
faculatative anaerobe
motile, polar flagellum

Question 7

V. cholerae serogroups?

Answer 7

O-1 antigen

O-139 (new strain)

Question 8

Cholera tx?

Prevention?

Answer 8

replace fluids/electrolytes

proper sewage control
vaccines (Shanchol, Dukoral)

Question 9

V. parahaemolyticus causes?

From?

Answer 9

milder cholera-like illness

from seafood

Question 10

V. vulnificus from?

Answer 10

oysters

open skin contact w/ seawater

Question 11

V. vulnificus sepsis caused by?

Results in?

tx?

Answer 11

immune-weakened raw oyster consumption

causes bullous leasions, shock

TCN but high mortality

Question 12

E. coli serogroup?

Answer 12

O-antigen (LPS)
O86 = normal flora
O55 = dx

Question 13

E. coli serotype?

Answer 13

H-antigen (flagella)

Question 14

E. coli pathogens distinguished how?

Answer 14

all look same

\\by unique path activity in host

Question 15

Enterotoxigenic E. coli (ETEC) causes?

Action?

Answer 15

Traveler’s D (resembles v. cholerae)

adheres small int mucosa

Question 16

Enterohemorrhagic E. coli (EHEC) causes?

Virulence factor?

Answer 16

D progressing to bloody D
(P) becomes hemolytic uremic syndrome (fatal), or renal F

Shiga-like toxin,
beef, raw milk

Question 17

EHEC SeroGT?

Diagnostic test?

Answer 17

O157:H7

MacConkey sorbitol agar = + white colonies
can’t ferment sorbitol

Question 18

EHEC tx?

Answer 18

oral hydration

Don’t use antimotility tx of kids

Question 19

Hemolytic Urenic Syndrome (HUS) caused by what 2 e. coli?

Answer 19

O157;H7

O104:H4

Question 20

Campylobacter jejuni source?

Microbe Characteristics?

Answer 20

poultry (esp undercooked), peaks in summer

G-
curved rod
motile
microaerophilic
42º

Question 21

C. jejuni presentation?

Answer 21

24 hrs pre-D: prodrome w/ fever, HA, myalgia

self-limiting several days,
contagious 2-3 wks

severe RLQ pain mimics appendicitis

Question 22

C. jejuni complications?

Answer 22

Reiters Synd

Guillain-Barre

Question 23

C. jejuni diagnosis by?

Answer 23

clinical: prodrome, fever

Question 24

H. pylori causes?

Source?

Answer 24

chronic gastritis, peptic ulcer

obscure
a/w adenocarcinoma

Question 25

H. pylori microbe characteristics?

Answer 25

G-
curved rods
high motile

Question 26

H. pylori action?

Presentation?

Answer 26

target epith cells in pylorus

cramps, N/V, halitosis

Question 27

H. pylori virulence factor?

Answer 27

Urease production ->

CO2 and NH4+

Question 28

H. pylori diagnostic test?

Answer 28

Stain in tissue bx w/ Giemsa,

CLO test = Huge urease

Question 29

H. pylori tx?

Answer 29

No ideal
TCN + bismuth
Sxs may continue past eradication