Bacterial GI II (lec 6) Flashcards
Shigella causes?
inflammation of large bowel
mod D to severe dysentery
Shigella microbe characteristics?
G- rod nonspore facultative anaerobe nonmotile nonlactose fermenting
invade colon epith cells
person-to-person transmission
Course of Shigellosis?
Classic:
fever, cramps, V/D –>
blood, mucous and PMN in stools
Shigella complications?
Reiter Synd
HUS
Reiter’s Synd?
acute inflammatory arthritis
inflamm eye dz
a/w HLA-B27 pts
Salmonellae microbe characteristics?
G- rod nonspore fac anaerobe motile nonlactose forming
Salmonellae presentation?
sudden onset
fever, V/D
2-3 days
Salmonellae diagnostics?
micro = fecal leukocytes»_space; PMN
Fluorescent Antibody test
serology typing
Salmonellae tx?
supportive
fluid/electr
Salmonellae vs. Shigella?
high dose microbe (need lots for dz), food/water transmission, (P) pets, carrier up to 1 yr vs p-to-p carrier for 2 mo
C. difficile causes?
pseudomemranous colitis (PMC) antibiotic-induced dz
C. diff microbe characteristics?
G+ rod
anaerobe
spore
C. diff presentation? (3 types)
1) D w/ mild cramping, no systemic sxs
2) severe colitis w/o pseudo (D w/ systemic sxs)
3) PMC (severe sxs + elevated yellow plaques in mucosa)
C. perfringens type A causes?
food-borne
moderate D dz/short duration
C. perfringens microbe characteristics?
G+ rod nonmobile aerotolerant anaerobe spore high dose
C. perfringens diagnostics?
isolate large # of microbes in feces/food
Bacillus cereus causes?
food-borne (esp. grain, veg)
D/V dz
B. cereus microbe characteristics?
G+ rod
Aerobic
motile
spore
B. cereus presentation?
Emetic:
pre-formed toxin
Upper GI
Diarrheal:
from ingested vegetative cells -> release toxin
Lower GI
B. cereus diagnostics?
afebrile
1-5 hr onset of emetic
5-17 hr onset of D
Staphylococcal foodborne dz?
acute, short lived D/V from pre-formed heat stable toxin,
2nd to salmonella in highest cause
Passed to food by people
Staph virulence factor?
Enterotoxin A:
H2O/heat stable
Staph diagnostics?
Afebrile
Short onset post custard, canned, potato salad
Enterotoxin test
Shigella tx?
fluids
self-limiting
(P) antibiotics (very resistant)
Shigella diagnostics?
blood/mucous in stool + acute onset
microscope = PMN, RBC in feces