Bacterial GI II (lec 6)

Question 1

Shigella causes?

Answer 1

inflammation of large bowel

mod D to severe dysentery

Question 2

Shigella microbe characteristics?

Answer 2

G- rod
nonspore
facultative anaerobe
nonmotile
nonlactose fermenting

invade colon epith cells
person-to-person transmission

Question 3

Course of Shigellosis?

Answer 3

Classic:
fever, cramps, V/D –>
blood, mucous and PMN in stools

Question 4

Shigella complications?

Answer 4

Reiter Synd

HUS

Question 5

Reiter’s Synd?

Answer 5

acute inflammatory arthritis
inflamm eye dz
a/w HLA-B27 pts

Question 6

Salmonellae microbe characteristics?

Answer 6

G- rod
nonspore
fac anaerobe
motile
nonlactose forming

Question 7

Salmonellae presentation?

Answer 7

sudden onset
fever, V/D
2-3 days

Question 8

Salmonellae diagnostics?

Answer 8

micro = fecal leukocytes&raquo_space; PMN

Fluorescent Antibody test

serology typing

Question 9

Salmonellae tx?

Answer 9

supportive

fluid/electr

Question 10

Salmonellae vs. Shigella?

Answer 10

high dose microbe (need lots for dz),
food/water transmission, (P) pets,
carrier up to 1 yr
vs 
p-to-p
carrier for 2 mo

Question 11

C. difficile causes?

Answer 11

pseudomemranous colitis (PMC)
antibiotic-induced dz

Question 12

C. diff microbe characteristics?

Answer 12

G+ rod
anaerobe
spore

Question 13

C. diff presentation? (3 types)

Answer 13

1) D w/ mild cramping, no systemic sxs
2) severe colitis w/o pseudo (D w/ systemic sxs)
3) PMC (severe sxs + elevated yellow plaques in mucosa)

Question 14

C. perfringens type A causes?

Answer 14

food-borne

moderate D dz/short duration

Question 15

C. perfringens microbe characteristics?

Answer 15

G+ rod
nonmobile
aerotolerant anaerobe
spore
high dose

Question 16

C. perfringens diagnostics?

Answer 16

isolate large # of microbes in feces/food

Question 17

Bacillus cereus causes?

Answer 17

food-borne (esp. grain, veg)

D/V dz

Question 18

B. cereus microbe characteristics?

Answer 18

G+ rod
Aerobic
motile
spore

Question 19

B. cereus presentation?

Answer 19

Emetic:
pre-formed toxin
Upper GI

Diarrheal:
from ingested vegetative cells -> release toxin
Lower GI

Question 20

B. cereus diagnostics?

Answer 20

afebrile
1-5 hr onset of emetic
5-17 hr onset of D

Question 21

Staphylococcal foodborne dz?

Answer 21

acute, short lived D/V from pre-formed heat stable toxin,
2nd to salmonella in highest cause
Passed to food by people

Question 22

Staph virulence factor?

Answer 22

Enterotoxin A:

H2O/heat stable

Question 23

Staph diagnostics?

Answer 23

Afebrile
Short onset post custard, canned, potato salad
Enterotoxin test

Question 24

Shigella tx?

Answer 24

fluids
self-limiting
(P) antibiotics (very resistant)

Question 25

Shigella diagnostics?

Answer 25

blood/mucous in stool + acute onset

microscope = PMN, RBC in feces