Heart failure treatment

Question 1

What drugs are given in HF? and why

Answer 1

Diuretic - fluid overload
ACE inhibitor - BP control
B blockers - reduce hr and force of contraction - allow proper filling. also by inhibiting sympathetic drive that can cause apoptosis of myocytes
Spironolactone - diuretic, retains K+ and unknown MOA acts as antifibrotic agent against metaloproteases.
Neutral Endopeptidase inhibitor
SGLT2 inhibitor - osmotic diuresis

Question 2

eg of b blocker

Answer 2

Bisoprolol , metoprolol

Question 3

e.g. of ACE inhibitor

Answer 3

Captopril, benazepril ( aka lotensin)

Question 4

names of SGLT2 inhibitors

Answer 4

…gliflozin

Question 5

MOA of NEPs

Answer 5

Neutral endopeptidase inhibitors prevent breakdown of BNP + allow longer duration of action i.e. prolong the body’s own coping mechanism

Question 6

How do ace inhibitors work?

Answer 6

Prevent conversion of ang1 to ang2 therefore decreases BP, stoops vasoconstriction
Important in HF because this reduces the pressure of the systemic system into which the LV has to pump blood
( also stop water retention -> lower bp, and prevents aldosterone production -> further prevention of diuretic action)