Heart Flashcards
Acts as false neurotransmitter
Guanadrel
MOA alpha blockers in control of BP
block post synaptic a1 receptors on smooth muscle
increases risk for Congestive Heart Failure in ALLHAT
DOXAZOCIN
“NHLBI advises these patients to find an alternative”
Cardioselective Beta blockers
Acebutolol Atenolol Betaxolol Bisoprolol Metoprolol
(AABBM)
Vasodilatory Beta blockers
Labetolol
Pindolol
Carvedilol
MOA Hydralazine
relax smooth muscle through fall in intracellular Ca concentration
MOA Minoxil
K channel opener
also diazoxide
SE first generation DHP CCBs
reflex tachycardia
stimulation of CNS
(Nifedipine is prototype)
Explain
Hypertension with OCPs containing estrogen
Contains ANGIOTENSINOGEN
can induce HPN
Most ACEIs are excreted renally except
Ramipril
Imidapril
(Renal and Hepatic)
Angiotensin receptor expressed only during injury
AT II
I is always expressed
Treatment of class 1a induced arrhythmias
SODIUM LACTATE
Class 1A drugs
QUINIDINE
PROCAINAMIDE
DISOPYRAMIDE
electrolyte changes exacerbate Digoxin Toxicity
Hypokalemia
Hypomagnesemia
Hypercalcemia
Rx arrythmia due to Digoxin Toxicity
LIDOCAINE
Phosphodiesterase inhibitors used in HF
MILRINONE
AMRINONE
MOA Amiloride
Inhibit Epithelial sodium channels in the cortical collecting duct
also potassium sparers
also Triamterene
Cause Gynecomastia
Spirinolactone Digoxin Cimetidine Alcohol Ketoconazole
Some Drugs Create Awesome Knockers
Site of Action ADH
Reabsorption of water under the control of ADH
ADH antagonists apart from the Vaptans
DEMECLOCYCLINE
LITHIUM
Thiazide diuretics
effect
HyperGLUC Hyperglycemia HyperLipidemia HyperUricemia HyperCalcemia
Inhibits NPC1L1 transporter, decreasing cholesterol absorption in intestine
EXETIMIBE
Cholesterol analog, sterol absorption blocker
SITOSTEROL
Pregnancy category of simvastatin
Category X
