Antipsychotics Antiparkinsons Flashcards
Antiparkinsons used in deterioration of drug effect in between doses
Entecapone
this is the “wearing off phenomenon”
Antiparkinsons used in alternating periods of improved mobility and akinesia during treatment
Apomorphine
“on-off phenomenon”
AE us erythromelalgia
Bromocripte
Antiparkinsons AE Gambling, hypersexuality
Pramipexole
Trimethobenzamine premedicate when taking ____ to prevent nausea
Apomorphine
Selegiline + ________ can cause fatal reaction
meperidine
Selegiline + ____________can cause serotonin syndrome
SSRIs
Antiparkinsons MAO Type B inhibitor
Selegiline
Antiparkinsons COMT inhibitor
Entecapone
Antiparkinsons Anticholinergic
Benztropine
Rx rabbit syndrome
Benztropine
Action Aripiprazole
D2 partial agonist
5HT 1A receptor
Dopamine hypothesis of Psychosis
Hyperactivity of dopaminergic systems
Antipsychotic causes agranulocytosis
Clozapine
Major metabolite of thioridazine, very poten
mesoridazine
Typical antipsychotics
Chlorpromazie
Thioridazine
Trifluoperazine
Haloperidol
Monoamine hypothesis of depression
serotonin
NE
dopamine
Contraindications antipsychotics
Depressed sensorium
Parkinsonism
Pregnancy
Respiratory depression
Lowers lithium levels
Acetazolamide
Theophyline
Amniophylline
Dose dependent AEs of phenytoin
20-30 Nystagmus, Ataxia
30-40 Mental changes, lethargy, dysarthria
40 Stupor
Antiseizure, initially as antifolate
lamotrigine
MOA Phenobarbital
Blocks Na and Ca
AE is megaloblastic anemia, osteomalacia
Phenobarbital
MC AE of ethosuximide
gastric distress
