Antibiotics Flashcards

1
Q

Very narrow spectrum penicillin

Resistant to beta lactamase

A

Nafcillin
Oxacillin
Cloxacillin

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2
Q

Extended spectrum penicillin

A

Amoxicillin

Ampicillin

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3
Q

Antimicrobial coverage of extended spectrum penicillin

A

Amoxicillin HELPS kill Enterococci

Hemophilus
E Coli
Listeria
Proteus
Salmonella
Enterococci
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4
Q

Synergistic with aminoglycosides against pseudomonas

A

Piperacillin

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5
Q

First gen cephalosporins are not active to

A

Enterococcus
Listeria
MRSA
Chlamydia Clostridium

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6
Q

Narrowest spectrum among aminoglycosides

A

Amikacin

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7
Q

Binds to 50s to inhibit translocation

A

erythromycin

clindamycin

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8
Q

The most vsetibulotoxic and nephrotoxic aminoglycosides

A

gentamicin

tobramycin

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9
Q

Most ototoxic antibiotic

A

Kanamycin

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10
Q

Nephrotoxic effect of Aminoglycosides

A

Acute tubular necrosis

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11
Q

short acting sulfonamide

A

sulfisoxazole

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12
Q

intermediate acting sulfonamide

A

sulfamethoxazole

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13
Q

long acting sulfonamide

A

sulfadoxine

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14
Q

selective inhibitors of bacterial dihydrofolate reductase

A

trimethoprim

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15
Q

competitive inhibitors of dihydropteroate synthase

A

sulfonamides

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16
Q

SE of silver sulfadiazine which is used in burn patients

A

Acute hemolysis in G6PD deficiency

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17
Q

Tendinitis and tendon rupture

A

ciprofloxacin

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18
Q

1st gen fluoroquinolones

A

nalidixic acid

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19
Q

2nd gen fluoroquinolones

A

ciprofloxacin, norfloxacin

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20
Q

3rd gen fluoroquinolones

A

levofloxacin
sparfloxacin
grepafloxacin

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21
Q

4th gen fluoroquinolone

A

moxifloxacin

22
Q

Why was grepafloxacin withdrawn

A

cardiotoxicity

23
Q

Bactericidal

A

Very Finely Proficient At Murder

Vancomycin
Fluoroquinolones
Penicillin
Aminoglycosides
Metronidazole
24
Q

Nitrofurantoin can be used for UTI except

A

Proteus

Pseudomonas

25
MOA metronidazole
reactive reduction by ferredoxin forming free radicals
26
Anti TB drug AE | Drug induced lupus
izoniazid
27
Antifungal inhibits microtubule formation
Griseofulvin
28
Antifungal inhibits squalene oxidase
Terbinafine
29
Antifungal inhibits glucan synthase
capsofungin
30
Drugs for influenza
A- Amantadine/ Rimantadine | A and B-Oseltamivir
31
Rx Hep B
IFN | Lamivudine
32
Rx Hep C
IFN | Ribavirin
33
Rx RSV infection
Ribavirin
34
DOC Malaria in pregnant patient
Quinine
35
SE of quinine
Cinchonism (Headache, tinnitus, vertigo) Hemolysis in G6PD deficient
36
Chemoprophylaxis multidrug resistant malaria
Doxycycline (S)- chloroquine 500 mg/tab 1 tab weekly chloroquine (R)- mefloquine 250 tab 1 tab weekly
37
DOC for uncomplicated malaria in the philippines
Artemether lumefantrine
38
Areas of high malarial endemicity
Palawan Ifugao Kalinga Apayao Agusan Del Sur
39
Areas of multidrug resistance
Palawan Davao Del Norte Compostela Valley
40
DOC african sleeping sickness
MELARSOPROL
41
DOC Advanced african sleeping sickness
EFLORNITHINE
42
DOC Chagas Disease
Nifurtimox
43
DOC Leishmaniasis
Sodium sibogluconate
44
DOC Toxoplasmosis
Pyrimethamine- Sulfadiazine
45
DOC Whipworm
Mebendazole
46
DOC flilaria
DEC
47
May cause mazotti in onchocerca
DEC
48
DEC Hookworm and roundworm
Pyrantel Palmoate
49
DOC Trichinosis
Thiabendazole
50
DOC Trematodes | Schistosoma, Paragonimus, Clonorchis...
Praziquantel