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Advanced Pharm Exam 4 > headache meds > Flashcards

headache meds Flashcards

1
Q

tension HA prophylaxis

A

TCAs, SNRIs, antiepileptics, botox

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2
Q

tension HA acute tx

A

APAP, NSAIDS, analgescs/caffeine

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3
Q

cluster HAs defining characteristics

A 
conjunctival lacrimation
nasal congestion
eyelid edema
forehead and facial sweating
miosis
IPSILATERAL

restlessness

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4
Q

cluster HA prophylaxis

A

galcanezumab

verapamil
lithium
topiramate
melatonin

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5
Q

cluster HA acute tx

A 
O2
triptans
octreotide
intranasal lidocaine *
dihydroergotamine
corticosteroids
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6
Q

triptans MOA

A

selective serotonin receptor agonists

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7
Q

most commonly used triptan w most dosage foms

A

sumatriptan

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8
Q

triptans routes onset

A

PO - 30-60 min
nasal - 10-15 min
SC - 10 min

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9
Q

triptans AE

A

tingling, flushing, tightness/pressure in chest (related to 5-HT)

injection site pain (SC)

CI in pts with CAD/HTN
avoid w other serotonin meds, MAOIs, propranolol, CYP3A4`

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10
Q

ditans MOA

A

serotonin receptor agonist

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11
Q

lasmiditan dosing

A

50-200 mg

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12
Q

ditans AE

A

dizziness, sedation, fatigue, paresthesia, bradycardia

avoid driving for 8 h

avoid w other CNS depressants & serotonin
avoid w BCRP and P-gp substrates

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13
Q

gepants MOA

A

CGRP receptor antagonist

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14
Q

00000

A

00000

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15
Q

rimegepant dosing

A

75 mg

also used for prevention

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16
Q

gepants AE

A

nausea, somnolence

avoid in CrCl <15
CYP3A4

17
Q

ergotamine MAO

A

nonselective serotonin agonist and vasoconstrictor

18
Q

ergotamine dosing

A

2mg sublingual

19
Q

ergotamine AEs

A

vasoconstriction! - vascular occlusion, gangrene, vasospasm, muscle aches, N/B+V

hepatic metabolsim

dihydroergotamine has less vascoconstriction

CYP3A4, CI w ischemic heart disease, HTN, triptan use, nicotine, pregnancy

20
Q

prophylaxis for migranes

A 
beta blockers
calcium channel blockers
TCAs
antiepileptics
SSRI/SNRIs
botox
CGRP blockers
21
Q

Indication for calcium gene-related peptid antagonist

A

migrane prevention

SC/IV
atogepant PO 10-30 mg

Advanced Pharm Exam 4 (13 decks)

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