ED meds Flashcards

1
Q

phosphodiesterase 5 inhibitors MOA

A

inhibition of PDE5 increases cGMP and results in smooth muscle relaxation and inflow of blood to the penis

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2
Q

PDE5 inhibitor education

A

may take 3-4 doses for effect
lasts 4-6 hours
increased efficacy w high fat meal (sildenafil and vardenafil)

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3
Q

PDE5 inhibitors PK

A

sildenafil - 30 min to 12 h

vardenafil - 30 min to 10 h
tadanafil - 60 min to 36 h - take continuously
avanafil - 15 min to 6 h

CYP3A4
not for use in hepatic impairment

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4
Q

PDE5 inhibitors AE

A

facial flushing, HA, indigestion, nasal congestion

vision alterations - stop immediately (sildenafil)
priapism > 4h
hemodynamic instability/cardiac events

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5
Q

PDE5 inhibitors interactions

A

CYP 3A4
nitrates contraindicated
alpha blockers - hypotension

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6
Q

alprostadil MOA

A

inhibits calcium ion channels in smooth muscle causing relaxation

onset 30-60 min

ok for post MI!!!

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7
Q

sildenafil dosing

A

50 mg PO QD PRN 1 h before sexual activity

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8
Q

vardenafil dosing

A

10 mg QD PRN 1 hr before sexual activity

also orally discintegrating

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9
Q

avanafil dosing

A

QD PRN 15 min before sexual activity

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10
Q

alprostadil AE

A

penis/testicle/groin pain, bleeding/spotting, dizziness, hTN

priapism

induction of labor in pregnant female sexual partner

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11
Q

alprostadil dosing

A

2.5 mcg injection intercavernosally up to 3x/week PRN

or interurethrally BID PRN

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