biologics Flashcards
hydrocortisone glucocorticoid/mineralocorticoid activity
duration
high glucocorticoid, some mineralocorticoid
short-acting
dexamethasone glucocorticoid/mineralocorticoid activity
duration
some gluco, no mineralo
long acting
fludrocortisone glucocorticoid/mineralocorticoid activity
duration
no gluco, very high mineralo
long-acting
prednisone/methylprednisolone gluco/mineral
duration
moderate, moderate
intermediate-acting
glucocorticoid AEs
poorly tolerated
hyperglycemia leukocytosis HPA axis insufficiency neuropsych effects osteopenia myopathy fluid retention gastritis
conventional synthetic DMARD examples & uses
methotrexate, leflunomide, sulfasalazine, hydroxychloroquine
RA
methotrexate uses
RA - first line, once weekly
IBD
conventional synthetic DMARDS AE
ALL - folic acid deficiency, bone marrow suppression, infection, hepatitis, teratogenic
methotrexate - stomatitis **folic acid supplementation reduces toxicity
lefluonomide - alopecia ** loooong half life
sulfasalazine - rash, SJS **avoid in pt w sulfa allergy
hydroxychloroquine use
used in RA for pt that are pregnant
hydroxychloroquine AE
ocular toxicitieies, increased skin pigmentation, QT PROLONGATION
JAK inhibitor AEs
infection, malignancy, THROMBOSIS, HLD
jak inhibitors examples
tofacitinib
baracitinib
upadacitinib
biologic meds characteristics
produced by living cell cultures large, complex, heavy molecules complex structures potentially immunogenic unstable and sensitive to external conditions
-mab medications
monoclonal antibodies
-cept medications
soluble receptor antagonist
etanercept