headache and migraine Flashcards
what is a primary headache and what are the (3) examples
headache in the absence of physical signs
migraine
cluster
tension
what is a secondary headache
2 examples
presence of physical signs
sinus headache
meningitis
defintion of normal headache
aka…
aka.. tension headache
disappears when noxious stimulus such as hunger or lack of sleep is resolved
which nerve cluster headache
trigeminal
cluster headaches last
30mins-3h same time of year
cluster headaches uni or bi-lateral
unilateral
Acute tx cluster headache
100% O2, 15l/m, non-rebreather mask
how does cluster headache O2 tx work
vasoconstriction
dx migraine
utterly fine between attacks
2/3
Light bothers you
Your headaches limit your ability to work, study or do what you need to do?
You feel nauseated or sick?
when does migraine start
48h before headache
which nt is released in migraine attack
serotonin
how do you measure increased serotonin
urine metabolites 5HIAA
what causes migraine aura
csd
Cortical Spreading Depression (CSD)
A transient and local suppression (depression)
…of spontaneous electrical activity in the cortex (cortical)
…which moves slowly across the brain (spreading)
what is CGRP, what is its role in migraine
trigeminovascular pathways
meningeal blood vessels dilate in response to serotonin
inflammatory neuropeptides such as CGRP leak out of dilated vessels
CGRP potentiates vasodilation
37 AA neuropeptide
what causes throbbing pain in migraine
activation of trigeminal ganglion
consider and explain this pathway
