Drug Dependence Flashcards
Drug abuse =
Drug dependence =
Drug tolerance =
Psychological dependence =
Physical dependence =
is a pattern of drug use in which the users consume the substance in amounts or using methods which are directly or indirectly harmful to themselves or others
is an adaptive state that develops after repeated drug use and which results in withdrawal symptoms upon cessation of drug use
the diminishing effect of a drug which results after repeated administration at a set dose
dependence that involves emotional–motivational withdrawal symptoms (e.g. dysphoria, depression, anhedonia, restlessness)
dependence that involves significant physical–somatic withdrawal symptoms (e.g. fatigue, nausea, seizures, pain, delirium tremens)
what are glutamate receptors called
NMDA
which is the most important pathway essential in addiction/experience of pleasure in reward
The dopaminergic projection from the ventral tegmental area
to the nucleus accumbens is essential in reward and drug-dependence
what happens to glucose metabolism in addicted brain
goes down. cold brain on PET scan
which gene is upregulated in chronic drug exposure
Delta FosB
alcohol acts on which receptors
GABA and NMDA
what receptors MDMA
5-HT uptake system
Dopamine uptake system
5-HT2 receptors
H2 histamine receptors
α2 adrenergic receptors
acute MDMA toxicity (6)
Temperature elevation
Disseminated intravascular coagulation
Rhabdomyolysis (blocked by dantrolene)
Increased renal reabsorbtion of water
Hyponatraemia
Cerebral oedema
chronic effect of MDMA abuse
loss of seratonergic neurons in the brain
cannabinergic receptors are called, where, and what type
CB1 (CNS), CB2 (periphery), GPCR
cannabinoid intoxication symptoms
hypothermia,
rigid immobility and decreased motor activity
are CB1 receptors pre or post synaptic. what do they do
pre, inhibitory
chronic cannabis use linked itwh which mental disorders
depression, memory problems, schizophrenia
