Headache

Question 1

Familial Hemiplegic Migraine

Name the three types with associated genes and resultant channelopathies

Answer 1

1. **FHM type1- Autosomal dominant**
 Chr 19 p13 (**CACNA1A gene**)- defect in P/Q calcium channel subunit
2. **FHM type 2- Autosomal dominant**
 chromosome 1q23 (**ATP1A2 gene**) defect in the A1A2 sodium-potassium ATPase channel
3. **FHM type 3- Autosomal dominant**
 Chromosome 2 q 24 (**SCN 1 A gene**) defect in presynaptic & postsynaptic voltage gated sodium channel