Headache Flashcards
What type of drugs are the triptans?
5HT1 antagonists
Are migraines more common with or without aura?
Without (70%)
Does pregnancy tend to exacerbate or cause remission from migraines?
Remission
Overuse of which medications can cause headaches?
Triptans
Opioids
Combination analgesics
What medications should be avoid when treating pain in migraine?
Opioids
What are the red flags when taking a headache history?
New onset headache > 55y/o Known/previous malignancy Immuno-suppressed Early morning headache Exacerbation by Valsalva
What is the most common type of migraine?
Without aura = 80%
With aura = 20%
How is migraine diagnosed?
At least 5 attacks
Duration 4-72 hours
2 of (unilateral, moderate/severe, pulsatile, worse on movement)
1 of (Autonomic features, photophobia/phonophobia)
What is the pathophysiology of migraine without aura ?
Stress triggers serotonin release
Blood vessels constrict & dilate
Chemicals irritate nerves and blood vessels causing pain
What is the pathophysiology of migraine with aura?
Cortical spreading depolarization
Activate trigeminal vascular system - dilate cranial blood vessels
Release of substance P, neurokinin A, CGRP
What is the migraine centre in the brain?
Dorsal raphe nucleus
Locus coenucleus
What is an aura?
Fully reversible visual, sensory, motor or language symptom (Visual most common)
What can trigger a migraine?
Sleep Diet Stress Hormonal Physical exertion
What is the treatment of a mild/moderate migraine?
NSAID or aspirin (second line= paracetamol-
What is the treatment of a severe migraine?
Prochlorperazine suppository & diclofenacsuppository
or
SC Sumatriptan