Headache

Question 1

Treats acute migraines

useful w infrequent n mild headaches ( wo nausea)

Answer 1

Excedrine

Question 2

Ergot alkaloid

Answer 2

Methysergide

Question 3

Act at alpha adrenergic, serotonergic, cns dopamine receptors

Answer 3

Methysergide

Question 4

Most effective when given prodromal

Answer 4

Methysergide

Question 5

Most effective when given prodromal-> dec inflammation, treats hyperprolactinemia

Answer 5

Methysergide

Question 6

Treats postpartum hemorrhage- only used after delievery, not prophylactic

Answer 6

Methysergide

Question 7

Abortive therapy for migraines

Answer 7

Methysergide

Question 8

Int

Propanolol, macrolides

Answer 8

Methysergide

Question 9

Int

Propanolol- vasoconstricts w pain n cyanosis
Macrolides- exacerbate ergot toxicity

Answer 9

Methysergide

Question 10

Drug INT w Methysergide

Answer 10

Propanolol, macrolides

Question 11

AD- hallucination, prolonged vasospasm, uterine SM contraction, Diarrhea, NV, fibrinoplastic changes, ergot poisoning-from ingesting infected grains

Answer 11

Methysergide

Question 12

GI absorption is aided by caffeine

Answer 12

Methysergide

Question 13

Selective serotonin agonists, similar to serotonin

Answer 13

Sumatriptan

Question 14

Uses- acute migraine treatment w , wo aura

Answer 14

Sumatriptan

Question 15

Int

Heart ds(should give to MI)- uncontrolled HTN, coronary heart ds,

ergot, MAOI’s, SSRI’S, -exacerbate prolonged vasospasm

CYP450 inhibitor- decrease triptan metabolism

Answer 15

Sumatriptan

Question 16

AD- taste alteration, NV, chest tightness, neck pain, nasal discomfort, increase bp, tingling n m weakness, hot flashes

Answer 16

Sumatriptan

Question 17

Simple and consistent but more selective, well established efficacy, less AD

Answer 17

Sumatriptan

Question 18

Short DOA, so you need several doses

Answer 18

Sumatriptan

Question 19

Zolmitriptan has been shown to be most potent agonist

• oral, subQ; significantly 1st pass effect
  Also available in nasal spray

Answer 19

Sumatriptan

Question 20

3 drugs of midrin

Answer 20

Isometheptene, dischlorphenazone, acetaminophen

Question 21

Isometheptene- vasoconsticts
Dischlorphenazone- mild sedation
Acetaminophen- pain relief

Answer 21

Midrin

Question 22

AD- NV, dizz, insomnia, transient numbness,

Answer 22

Midrin

Question 23

To treat migraines for pt that doesnt take ergots

Answer 23

Midrine

Question 24

Cons- less effective than ergot

Answer 24

Midrin

Question 25

NMDA antagonist

Answer 25

Memantine

Question 26

Blocks neuronal excitation( blocks migraine pain)

Answer 26

Memantine

Question 27

Uses- migraine treatment and also AD treatment

Answer 27

Memantine

Question 28

3 drugs of excedrine

Answer 28

Acetaminophen, aspirine, caffeine