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Pharm > Headache > Flashcards

Headache Flashcards

1
Q

Treats acute migraines

useful w infrequent n mild headaches ( wo nausea)

A

Excedrine

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2
Q

Ergot alkaloid

A

Methysergide

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3
Q

Act at alpha adrenergic, serotonergic, cns dopamine receptors

A

Methysergide

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4
Q

Most effective when given prodromal

A

Methysergide

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5
Q

Most effective when given prodromal-> dec inflammation, treats hyperprolactinemia

A

Methysergide

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6
Q

Treats postpartum hemorrhage- only used after delievery, not prophylactic

A

Methysergide

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7
Q

Abortive therapy for migraines

A

Methysergide

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8
Q

Int

Propanolol, macrolides

A

Methysergide

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9
Q

Int

Propanolol- vasoconstricts w pain n cyanosis
Macrolides- exacerbate ergot toxicity

A

Methysergide

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10
Q

Drug INT w Methysergide

A

Propanolol, macrolides

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11
Q

AD- hallucination, prolonged vasospasm, uterine SM contraction, Diarrhea, NV, fibrinoplastic changes, ergot poisoning-from ingesting infected grains

A

Methysergide

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12
Q

GI absorption is aided by caffeine

A

Methysergide

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13
Q

Selective serotonin agonists, similar to serotonin

A

Sumatriptan

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14
Q

Uses- acute migraine treatment w , wo aura

A

Sumatriptan

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15
Q

Int

Heart ds(should give to MI)- uncontrolled HTN, coronary heart ds,

ergot, MAOI’s, SSRI’S, -exacerbate prolonged vasospasm

CYP450 inhibitor- decrease triptan metabolism

A

Sumatriptan

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16
Q

AD- taste alteration, NV, chest tightness, neck pain, nasal discomfort, increase bp, tingling n m weakness, hot flashes

A

Sumatriptan

17
Q

Simple and consistent but more selective, well established efficacy, less AD

A

Sumatriptan

18
Q

Short DOA, so you need several doses

A

Sumatriptan

19
Q

Zolmitriptan has been shown to be most potent agonist

  • oral, subQ; significantly 1st pass effect
    Also available in nasal spray
A

Sumatriptan

20
Q

3 drugs of midrin

A

Isometheptene, dischlorphenazone, acetaminophen

21
Q

Isometheptene- vasoconsticts
Dischlorphenazone- mild sedation
Acetaminophen- pain relief

A

Midrin

22
Q

AD- NV, dizz, insomnia, transient numbness,

A

Midrin

23
Q

To treat migraines for pt that doesnt take ergots

A

Midrine

24
Q

Cons- less effective than ergot

A

Midrin

25
Q

NMDA antagonist

A

Memantine

26
Q

Blocks neuronal excitation( blocks migraine pain)

A

Memantine

27
Q

Uses- migraine treatment and also AD treatment

A

Memantine

28
Q

3 drugs of excedrine

A

Acetaminophen, aspirine, caffeine

Pharm (19 decks)

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