Calcium Ch Blocker---EXAM 2

Question 1

Ca ch blockers

Answer 1

Dihydropyridine

Benzythiazepines

Diphenylalkylamines

Question 2

Dihydropyridines

Answer 2

Amlodopine- no effect on AV node conduc
Felodipine
Isradipine
Nicardipine
Nifedipine- not effect on AV node conduc
Nimodipine- treats subarachnoid hemorrhage
Nisoldipine

Question 3

Dec BP, no affect HR

Answer 3

Dihydropyridines

Question 4

No effect on AV node conduct

Low effect on contraction and HR

Answer 4

Amlodipine

Nifedipine

Question 5

Cause peripheral release capsules that have been used for rapid reductions in BP, but the risks outweigh the benefits

Answer 5

Nifedipine

Question 6

Largest acting (40h) of Dihydropyridine

Answer 6

Amlodipine

Question 7

Shortest acting in dihydropyridine

Answer 7

Nifedipine

Question 8

IND

Dihydropyridine

Answer 8

HTN- indicated for all dihydropyridines excep nimodipine

Angina- indicated for amlopine, nicardipine, difedipine

Question 9

Contra IND

Dihydropyridines

Answer 9

HTN emergencies- short acting, acute MI, acute smoke

Question 10

AD

Dihydropyridine

Answer 10

Peripheral edema, reflex tachycardia, gingival hyperplasia, headache, flushing, rash, dizziness, hypotension

Question 11

INT

Dihydropyridines

Answer 11

Grapefruit juice, H2 receptor antagonists

Question 12

Use is controversy
3rd line therapy for angina
Drug INT can cause severe toxicities

Answer 12

Ca channer blocker

Question 13

Diltiazem

Answer 13

Benzythiazepines

Question 14

Ind

Benzythiazepines (diltiazem)

Answer 14

HTN, angina, arterial fibrillation, arrhythmia

Question 15

IND

Benzythiazepine, diphenylalkylamine

Answer 15

HTN, angina, arterial fibrillation, arrhythmia

Question 16

AD

Benzythiazepine, diphenylalkylamine

Answer 16

Peripheral edema, hypotension, nausea, dizzness, heart block, bradycardia, negative inotrope

Diphenylalkylamine-> constipation

Question 17

INT

Benzythiazepine

Answer 17

H2 receptor ant,

B blockers

Inc carbamazepine, cyclosporine, digoxin, quinidine

Question 18

Dec BP, dec SA, inc AV

Answer 18

Benzythiazepines, diphenylalkylamines

Question 19

AD

Constipation

Answer 19

Verapamil (diphenylalkylamines)

Question 20

Many binding sites

Answer 20

L channers

Question 21

In SM, heart, brain, adrenal, kidney

Answer 21

L channel

Question 22

Blocking L channel->

Answer 22

Inhibit m contraction: SM dilation, dec contractility, dec HR (slow SA node firing and inc AV nodal refractory time)

Question 23

Has 1 drug binding site

Answer 23

T channel

Question 24

In BV, pathologic heart, brain, adrenal, kidney

Answer 24

T channel

Question 25

Blocking T channel->

Answer 25

Vasodilation, inc myocardial BF, dec HR