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Pharm > Diuretics-----EXAM2 > Flashcards

Diuretics-----EXAM2 Flashcards

1
Q

MOA

Dec formation of aqua humor
Dec sodium bicarb reabsorp in PCT-> causing meta acidosis

A

Carbonic anhydrase inh

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2
Q

IND

Carbonic anhydrase inh

A

Glaucoma- dec intra ocular P
Acute altitude sickness
Epilepsy

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3
Q

Contra IND

Carbonic anhydrase inh

A

Hepatic ds, Renal ds

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4
Q

AD

Carbonic anhydrase inh

A

Metallic taste
Black stools,
Bone marrow supression
Hyperchloremic met acidosis

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5
Q

MOA

Osmotic

A

Inc water volume in neph
(No reabsorb solutes)

  • pull water out of systemic circulation and pee it out
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6
Q

Osmotic diuretic drug

A

Mannitol

Affects thin descending loop

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7
Q

IND

Osmotic

A

Dec intra cranial P, inc urine output

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8
Q

Contra IND

Osmotic

A

Anuria
Heart failure w w/o pul. Edema
Renal dysfunction

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9
Q

AD

Osmotic

A 
Initial hyponatremia
Later hypernatremia in collecting duct 
Headache
NV
Dehydration
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10
Q

Diuretics

C O L T PO VA

A 
carbonic anhydrase inhib
Osmotic 
Loop
Thiazide
Potassium sparing
Vasopressin/ADH ant
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11
Q

MOA

Loop

A

Block reabsorption of Cl in thick ascending, cause Na and H2O to follow

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12
Q

Loop diuretic drugs

BET Fur

A

Bumetanide
Ethacrynic acid (sulfur allergy pt, but sever AD)
Torsemide
Furosemide

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13
Q

IND

Loop

A 
1st line for heart failure
Acute renal failure (loops work in renal failure, where other diuretics doesnt)
Hyperkalemia
Anion Overdose
Acute pul edema
Hypertension
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14
Q

1st line for heart failure

A

Loop

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15
Q

Acute renal failure (loops work in renal failure, where other diuretics doesnt)

A

Loop

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16
Q

Contra Ind

Loop

A

Anuria

Pt w sulfonamide allergies- will be allergic to all loops except ethacrynic acid

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17
Q

INT

Loop

A

NSAID

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18
Q

AD

Loop

A

Hypocal, hypokal, hypomag, hypocl (meta alkal)

Ototoxicity-hearing loss

Hyperuricemia- can cause gout

Allergic rxn to sulfa drugs

Azotemia( inc nitr)

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19
Q

AD

Met alkal

20
Q

AD

Ototoxicity

21
Q

MOA

Thiazide

A

Inh NaCl reabsorp in DCT

Inc Ca reabsorp in DCT

22
Q

Thiazide

A

Hydrochlorothiazide

Metolazone

23
Q

IND

Thiazide

A

Ist line for hypertension

Congestive heart failure + loop diuretics

Nephrolithiasis (kidney stone)

Diabetes insipidus

24
Q

INT

Thiazide

A

Cal lin

Calcium supplement
Lithium
NSAID

25
AD Thiazide
Hypokalemia, hyperuricemia, hypercalcemia, glucose intolerance, hyperlipidemia, hyponatremia, allergic rxn(rash)
26
AD Hypocal, hypokal
Loop
27
AD Hypokal, hypercal
Thiazide
28
AD Glucose intolerance Hyperlipidemia
Thiazide
29
AD Gynecomastia (male boop) Hyperkal
Potassium sparing
30
MOA Vasopressin/ADH ant
Inh ADH in collecting ducts ( free water excretion)
31
Vasopressin/ADH ant
Conivaptan, | Tolvaptan
32
IND Vasopressin/ADH ant
Syndrome of inappropriate ADH secretion. | Hypervolemic hyponatremia-like in heartfailure
33
Potassium sparing diuretics SAT
Spiromolactone/Eplerenone Amiloride Triamterene
34
MOA Potassium sparing diuretics- spiromolactone/eplerenone
Inhib aldosterone effects in cortical collecting tube and later distal tube
35
IND Potassium sparing diuretics- spiromolactone/eplerenone
HTN, heart failure post MI (especially Eplerenone) Prim aldosteronism, Hypokalemia, Edema secondary to cirrhosis
36
Contra IND Potassium sparing diuretics- amiloride, triamterene
Renal dysfunction Hyperkalemia
37
INT Potassium sparing diuretics- triamterene
Potassium supplement ACE inhi NSAID
38
AD Potassium sparing diuretics- spironolactone, eplerenone
Hyperkalemia- but not if used w thiazides or loops Hypotension, rash, headache, nausea Constipation Gynecomastia
39
MOA Amiloride, Triamterene
Inhi Na transport thru ch in cortical collecting tube and late distal tubule
40
IND Amiloride, Triamterene
Hypokalemia, edema
41
Contra IND Amiloride, Triamterene
Hyperkalemia Severe renal dysfunc (Amiloride- hepatic dysfuc)
42
INT Amiloride, Triamterene
NSAID, ACE inhi Potassium supplement (Amiloride- Lithium)
43
Contra- AD Hyperkalemia Severe renal dysfunc Hepatic dysfunc
Amiloride
44
AD Amiloride,
``` Hyperkalemia Abdo. Discomf Diarrhea Headache Dec appetite Impotence ```
45
AD Triamterene
Hyperkalemia Abdo. Discom Hyponatremia Megaloblastic anemia

Pharm (19 decks)

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