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Pharm > Diuretics-----EXAM2 > Flashcards

Diuretics-----EXAM2 Flashcards

1
Q

MOA

Dec formation of aqua humor
Dec sodium bicarb reabsorp in PCT-> causing meta acidosis

A

Carbonic anhydrase inh

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2
Q

IND

Carbonic anhydrase inh

A

Glaucoma- dec intra ocular P
Acute altitude sickness
Epilepsy

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3
Q

Contra IND

Carbonic anhydrase inh

A

Hepatic ds, Renal ds

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4
Q

AD

Carbonic anhydrase inh

A

Metallic taste
Black stools,
Bone marrow supression
Hyperchloremic met acidosis

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5
Q

MOA

Osmotic

A

Inc water volume in neph
(No reabsorb solutes)

  • pull water out of systemic circulation and pee it out
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6
Q

Osmotic diuretic drug

A

Mannitol

Affects thin descending loop

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7
Q

IND

Osmotic

A

Dec intra cranial P, inc urine output

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8
Q

Contra IND

Osmotic

A

Anuria
Heart failure w w/o pul. Edema
Renal dysfunction

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9
Q

AD

Osmotic

A 
Initial hyponatremia
Later hypernatremia in collecting duct 
Headache
NV
Dehydration
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10
Q

Diuretics

C O L T PO VA

A 
carbonic anhydrase inhib
Osmotic 
Loop
Thiazide
Potassium sparing
Vasopressin/ADH ant
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11
Q

MOA

Loop

A

Block reabsorption of Cl in thick ascending, cause Na and H2O to follow

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12
Q

Loop diuretic drugs

BET Fur

A

Bumetanide
Ethacrynic acid (sulfur allergy pt, but sever AD)
Torsemide
Furosemide

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13
Q

IND

Loop

A 
1st line for heart failure
Acute renal failure (loops work in renal failure, where other diuretics doesnt)
Hyperkalemia
Anion Overdose
Acute pul edema
Hypertension
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14
Q

1st line for heart failure

A

Loop

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15
Q

Acute renal failure (loops work in renal failure, where other diuretics doesnt)

A

Loop

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16
Q

Contra Ind

Loop

A

Anuria

Pt w sulfonamide allergies- will be allergic to all loops except ethacrynic acid

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17
Q

INT

Loop

A

NSAID

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18
Q

AD

Loop

A

Hypocal, hypokal, hypomag, hypocl (meta alkal)

Ototoxicity-hearing loss

Hyperuricemia- can cause gout

Allergic rxn to sulfa drugs

Azotemia( inc nitr)

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19
Q

AD

Met alkal

A

Loop

20
Q

AD

Ototoxicity

A

Loop

21
Q

MOA

Thiazide

A

Inh NaCl reabsorp in DCT

Inc Ca reabsorp in DCT

22
Q

Thiazide

A

Hydrochlorothiazide

Metolazone

23
Q

IND

Thiazide

A

Ist line for hypertension

Congestive heart failure + loop diuretics

Nephrolithiasis (kidney stone)

Diabetes insipidus

24
Q

INT

Thiazide

A

Cal lin

Calcium supplement
Lithium
NSAID

25
Q

AD

Thiazide

A

Hypokalemia, hyperuricemia, hypercalcemia, glucose intolerance, hyperlipidemia, hyponatremia, allergic rxn(rash)

26
Q

AD

Hypocal, hypokal

A

Loop

27
Q

AD

Hypokal, hypercal

A

Thiazide

28
Q

AD

Glucose intolerance
Hyperlipidemia

A

Thiazide

29
Q

AD

Gynecomastia (male boop)
Hyperkal

A

Potassium sparing

30
Q

MOA

Vasopressin/ADH ant

A

Inh ADH in collecting ducts ( free water excretion)

31
Q

Vasopressin/ADH ant

A

Conivaptan,

Tolvaptan

32
Q

IND

Vasopressin/ADH ant

A

Syndrome of inappropriate ADH secretion.

Hypervolemic hyponatremia-like in heartfailure

33
Q

Potassium sparing diuretics

SAT

A

Spiromolactone/Eplerenone
Amiloride
Triamterene

34
Q

MOA

Potassium sparing diuretics- spiromolactone/eplerenone

A

Inhib aldosterone effects in cortical collecting tube and later distal tube

35
Q

IND

Potassium sparing diuretics- spiromolactone/eplerenone

A

HTN, heart failure post MI (especially Eplerenone)

Prim aldosteronism,

Hypokalemia, Edema secondary to cirrhosis

36
Q

Contra IND

Potassium sparing diuretics- amiloride, triamterene

A

Renal dysfunction

Hyperkalemia

37
Q

INT

Potassium sparing diuretics- triamterene

A

Potassium supplement

ACE inhi

NSAID

38
Q

AD

Potassium sparing diuretics- spironolactone, eplerenone

A

Hyperkalemia- but not if used w thiazides or loops

Hypotension, rash, headache, nausea

Constipation

Gynecomastia

39
Q

MOA

Amiloride, Triamterene

A

Inhi Na transport thru ch in cortical collecting tube and late distal tubule

40
Q

IND

Amiloride, Triamterene

A

Hypokalemia, edema

41
Q

Contra IND

Amiloride, Triamterene

A

Hyperkalemia
Severe renal dysfunc

(Amiloride- hepatic dysfuc)

42
Q

INT

Amiloride, Triamterene

A

NSAID, ACE inhi

Potassium supplement

(Amiloride- Lithium)

43
Q

Contra- AD

Hyperkalemia
Severe renal dysfunc
Hepatic dysfunc

A

Amiloride

44
Q

AD

Amiloride,

A 
Hyperkalemia
Abdo. Discomf
Diarrhea
Headache
Dec appetite
Impotence
45
Q

AD

Triamterene

A

Hyperkalemia
Abdo. Discom
Hyponatremia
Megaloblastic anemia

Pharm (19 decks)

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