B Blockers---EXAM2

Question 1

B 1 blocker

Met At Ace By Esmol

Answer 1

Metoprolol
Atenolol
Acebutolol
Bisoprolol
Esmolol

Question 2

B 1:

B2:

Answer 2

b1-Inc HR, inc Cont

B2- vasodilation, bronchodilation

Question 3

B blocker

Answer 3

Dec contrac n HR (b1)
Inc peripheral vasc resis (b2)
Causes bronchospasm (do not give in asthma pt)

Question 4

100 % renally excreted so you need to check renal function first

Answer 4

Nadolol

Question 5

Has ISA

Answer 5

Pindolol (b)

Acebutolol (b1)

Question 6

50% renal clearance

Answer 6

Atenolol

Question 7

Broken down by blood esterases

Answer 7

Esmolol

Question 8

B 1 blocker

Answer 8

Dec contract n HR

High dose-> selectives are less
Low doses-> more selective

** no b 2 effect -> better for asthma

Question 9

ISA (intrinsic sympathomimetic activity)

Answer 9

Acebutolol, pindolol
B blockers are partial agonists in low catecholaminenstates
- resting pt= low level of b- blocking activity
- active pt= veeeeeery high level of b- blocking activity

Prevents resting bradycardia->bc if it had high activity (of decreasing HR) during rest, the person would pass out

Question 10

Inhibit catecholamine induced renin release from kidneys, basically inhibiting renin- angiotensin-aldosterone system

Answer 10

B blockers

Question 11

IND

b blockers

Answer 11

For

Hypertension, ischemic heart ds, arrhythmias, heart failure, migraines, glaucoma

(Heart failure- metoprolol, bisoprolol, carvedilol)

Question 12

Contra IND

b blockers

Answer 12

Absolute contra- allergy, asthma, heart block, severe diabetes

Relative contra- COPD, DM, Vascular insufficiency

Question 13

INT

B blockers

Answer 13

(Slowing AV node comduction)- Digoxin, diltiazem, verapamil

NSAID- (vasoconstrict kidney, causing it to retain water)

BP meds

Inducers of hepatic metabolism of drugs- rifampin, phenobarbital, phenytoin
-> drugs would be metabolized too quick and wouldnt be effective. (Do not affect Nadolol)100%excreted

Question 14

AD

B blockers

Answer 14

Bradycardia, heart block, fatigue, bronchospasm, impotence, difficulty excercising

Question 15

B blockers (considerations)

Pt w bronchospastic lung ds->

Answer 15

Shouldnt receive b blockers

Question 16

B blockers (considerations)

Be careful w diabetics

Answer 16

B blockers mask symptoms of hypoglycemia, so you couldnt tell if a diabetic was having an attack
-> diabetics need to monitor their blood glucose on b-blockers closely

Question 17

B blockers (considerations)

No abrupt stops

Answer 17

Re-bound hypertension occurs w abrupt discontinuation

Question 18

Non selective

Answer 18

Nadolol
Propanolol
Pindolol