B + a1 Blockers/a1 blocker/a2 blocker----EXAM2 Flashcards

1
Q

3 rd gen nonselective
Dec cont and HR
Vasodilate (a1)

A

Carvedilol,

Labetalol

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2
Q

4th gen, b1 selective

A

Nebivolol

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3
Q

IND

Hypertension, compensated heard failure

A

Carvedilol

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4
Q

Int (carvedilol)

Ride blood in ca ci

A
Rifampin
Digoxin
Blood pressure meds
Ca ch blockers
Cimetidine (inhi elimination)
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5
Q

INT

Rifampin
Digoxin
Blood pressure meds
Ca ch blockers
Cimetidine (inhi elimination)
A

Carvedilol

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6
Q

AD

Sexual dysfunction, depression, dyslipidemia, sleep disturb, bradycardia, hypotension, dizziness, fatigue

A

Carvedilol

Labetalol

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7
Q

IND (Labetalol)

A

Hypertension(oral), hypertensive emergemcies (IV),

Hypertension due to pheochromocytoma

Acute aortic disection

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8
Q

IND

Hypertension(oral), hypertensive emergemcies (IV),

Hypertension due to pheochromocytoma

Acute aortic disection

A

Labetalol

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9
Q

INt (labetalol)

A

BP meds, cimetidine(inhi elimination)

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10
Q

IV labetalol

A

More b blocking activity than a blocking activity(7:1)

Oral-> 3:1=b:a

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11
Q

B + a1 blockers

Car lab navi

A

Carvedilol
Labetalol
Nebivolol

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12
Q

a 1 blocker

A

Vasodilate- inhi catecholamine (lower BP)

Dec afterload of heart,
Dec peripheral vascular resistance

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13
Q

a1 blocker

Aldo 에서 Tam나는 The Prada 신발 만듬

A

Alfuzosin- prostate selective for BPH

Doxazosin

Tamsulosin- prostate sele for BPH

Terazosin
Prazosin

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14
Q

IND

a1 blocker

A

Hypertension,
Peripheral vascular ds (claudication)

Used in heart failure secondary to development of tachyphylaxis (not primary)

Benign prostate hypertrophy- only for tamsulosin and alfuzosin

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15
Q

INT

a1 blocker

A

Verapamil, BP meds, NSAID

Verapamil- inc prazosin drug level

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16
Q

AD

a1 blocker

A

Orthostatic hypotension- only after first dose(first dose effect)
-> inc risk in pt w sodium and water depletion

Dizzi, lightheadness, headache, drowsiness

17
Q

a1 blocker

A

Most pt require additional diuretic to help blunt sodium and water resorption

No deterious effect on lipid profiles

18
Q

a 2 blockers

GQ MC

A

Guanabenz
Quanfacine
Methyldopa- tears hypertensive emergencies in preg
Clonidine- (ad) sedation, drowsiness

19
Q

MOA

a 2 blockers

A

Blocks presynaptic a2 receptors located in CNS -> dec symp

Lower BP and HR- not 1st line drugs for HR though

20
Q

IND

a 2 blockers

A

Hypertension,
Heroin, alcohol, smoking withdrawal
Hypertensive emergencies
Menopausal hot flashes

21
Q

INT

a 2 blockers

A

TCA

B blockers: inc rebound effect when stopping therapy -> worsen clonidine withdrawal

22
Q

AD

a 2 blockers

A

Sedation
Dry mouth, depression
Drowsiness, dizzness->!side effects only for methyldopa: drug induced fever and lupus

23
Q

Abrupt d/c leads to severe rebound hypertension -> worsened by b-blockers

Titrate doses slowly- limit sedation

A

a 2 blockers