B + a1 Blockers/a1 blocker/a2 blocker----EXAM2 Flashcards
3 rd gen nonselective
Dec cont and HR
Vasodilate (a1)
Carvedilol,
Labetalol
4th gen, b1 selective
Nebivolol
IND
Hypertension, compensated heard failure
Carvedilol
Int (carvedilol)
Ride blood in ca ci
Rifampin Digoxin Blood pressure meds Ca ch blockers Cimetidine (inhi elimination)
INT
Rifampin Digoxin Blood pressure meds Ca ch blockers Cimetidine (inhi elimination)
Carvedilol
AD
Sexual dysfunction, depression, dyslipidemia, sleep disturb, bradycardia, hypotension, dizziness, fatigue
Carvedilol
Labetalol
IND (Labetalol)
Hypertension(oral), hypertensive emergemcies (IV),
Hypertension due to pheochromocytoma
Acute aortic disection
IND
Hypertension(oral), hypertensive emergemcies (IV),
Hypertension due to pheochromocytoma
Acute aortic disection
Labetalol
INt (labetalol)
BP meds, cimetidine(inhi elimination)
IV labetalol
More b blocking activity than a blocking activity(7:1)
Oral-> 3:1=b:a
B + a1 blockers
Car lab navi
Carvedilol
Labetalol
Nebivolol
a 1 blocker
Vasodilate- inhi catecholamine (lower BP)
Dec afterload of heart,
Dec peripheral vascular resistance
a1 blocker
Aldo 에서 Tam나는 The Prada 신발 만듬
Alfuzosin- prostate selective for BPH
Doxazosin
Tamsulosin- prostate sele for BPH
Terazosin
Prazosin
IND
a1 blocker
Hypertension,
Peripheral vascular ds (claudication)
Used in heart failure secondary to development of tachyphylaxis (not primary)
Benign prostate hypertrophy- only for tamsulosin and alfuzosin
INT
a1 blocker
Verapamil, BP meds, NSAID
Verapamil- inc prazosin drug level
AD
a1 blocker
Orthostatic hypotension- only after first dose(first dose effect)
-> inc risk in pt w sodium and water depletion
Dizzi, lightheadness, headache, drowsiness
a1 blocker
Most pt require additional diuretic to help blunt sodium and water resorption
No deterious effect on lipid profiles
a 2 blockers
GQ MC
Guanabenz
Quanfacine
Methyldopa- tears hypertensive emergencies in preg
Clonidine- (ad) sedation, drowsiness
MOA
a 2 blockers
Blocks presynaptic a2 receptors located in CNS -> dec symp
Lower BP and HR- not 1st line drugs for HR though
IND
a 2 blockers
Hypertension,
Heroin, alcohol, smoking withdrawal
Hypertensive emergencies
Menopausal hot flashes
INT
a 2 blockers
TCA
B blockers: inc rebound effect when stopping therapy -> worsen clonidine withdrawal
AD
a 2 blockers
Sedation
Dry mouth, depression
Drowsiness, dizzness->!side effects only for methyldopa: drug induced fever and lupus
Abrupt d/c leads to severe rebound hypertension -> worsened by b-blockers
Titrate doses slowly- limit sedation
a 2 blockers