Alzheimer--------------------------------------------------EXAM2 Flashcards
Rivastigmine (Exelon)
Carbamate, AchE inhi
Inc *10 affinity for brain
Rivastigmine (Exelon)
Use for mild to moderate Alzheimer
Rivastigmine (Exelon)
Galantamine
Tacrine
Donepezil
(Except Mementine)
AD
Headache, NVD
Rivastigmine (Exelon)
Long DOA
Available in patch for pt who doesnt remember to take it
Rivastigmine (Exelon)
NMDA ant
Memantine
Treat severe Alzheimer
Memantine
AD
Constipation, hypertension, cough, somnolence, headache, fatigue,
Memantine
Used alone or w an AchE inh
Comes in patch form
Memantine
AchE inh
Rivastigmine
Galantamine
Tacrine
Donepezil
Reversible, competitive,
Selective for brain AchE
Carbamate compound
Galantamine
Uses
Treat mild to moderate alzheimer
Galantamine
AD
GI prob, agitation, insomnia
Galantamine
AchE inh
Butyrylcholinesterase inh
Tacrine- cognex
Uses
Treats mild to moderate alzheimer (inc memory and cognition)
Tacrine
Int
Cimetidine (decrease clearance by 30%)
Tacrine
AD:
Hepatotoxicity- occurs in 1st 8wks in 30% of pts
NVD
Agitation, anorexia
Tacrine
Must be given every 6 h on an empty stomach
Increase dose over 12 wks to decrease AD
Tacrine
AchE inh
Reversible, noncompetitive
Patch
Donepezil
Uses
1st line of defense for Alzheimer, treats mild to moderate alzheimer
Donepezil
No liver toxicity, given once daily(why it’s chosen over Tacrine)
Donepezil
Has low peripheral activity (high selectivity for CNS AchE)
2 yrs later -> doesnt have effect
Donepezil
Other treatment
Estrogen repel treat- possibly neuroprotective
Ginko-> not really used (INT: anti-platelet drug)
Antidepressants, antipsychotics-> to help mood, behavior disturbances
Alzheimer’s ds
RiD MEGA Tackle
Rivastigmine Donepezil, Aricept Memantine Galantamine Tacrine, cognex
