Hazardous Drug Preparation Part 10

Question 1

Immunomodulating agents inhibit growth of the ____

Answer 1

cells

Question 2

Miscellaneous agents are mitotic inhibitors, which means they interfere with cellular ____

Answer 2

division

Question 3

What is intermittent therapy?

Answer 3

Where high doses are given weekly or monthly, with a “rest period” in between

Question 4

Occupational exposure can result in skin rashes, adverse reproductive effects, and even ____

Answer 4

cancer

Question 5

What are the steps to preparing a Hazardous (Chemotherapy) Preparation?

Answer 5

1. Complete any calculations needed and prepare label before entering the ISO class 8 ante area.
2. Perform handwashing and garbing
3. Ensure the biologic safety cabinet (BSC) has been cleaned and is on.
4. Stage the medication, bag, label, and supplies needed on a (work surface) stainless-steel cart beside the BSC.
5. Lay out the mat in the BSC and items needed for priming the bag.
6. Prime the IV bag with clean fluid by attaching the spike end of the tubing to the bag. Allow fluid to reach the end of the tubing and then clamp the line off.
7. Place primed bag with its tubing to the side and add other items in the BSC, one at a time, maintaining correct spacing of at least 6 inches, spraying each item with sterile isopropyl alcohol (IPA )70%, and removing outer packaging at the edge of the hood.
8. Before spiking the vial of HD medication, discard all trash possible (before exposure to the chemo drug) in regular trash or sharps if needed.
9. Attach the CTSD to the medication vial without touching the critical site areas (spike end).
10. Withdraw the contents using just a syringe attached via luer lock to the CSTD. There will be no need for using the seesaw method or removing air bubbles, since the CSTD is a vented, closed transfer system.
11. Add a needle to the filled syringe and inject the medication into the IV bag and affix a seal on the port of the bag.
12. Inspect the bag for leaks, cloudiness, or particulate matter. Place the labeled bag in a labeled or marked as HAZARDOUS/CHEMO delivery bag. Wipe the bag with an alcohol wipe.
13. Discard unneeded items except vial, mat, and prepared compound. Lay out both the syringe drawn back to amount added and the drug inside the BSC and ask for a Pharmacist check.
14. Once the bag is checked, it can be removed. While still sitting at the BSC, discard trash and medication in the appropriate containers (yellow sharps for the syringe, needle, medication) and yellow container for the mat, only the OUTER pair of gloves, supplies, and any other items left in BSC.
15. Remove PPE (HD) including the INNER (second) set of gloves outside BSC and place in larger hazardous waste container in the ISO Class 7 area.
16. Wash hands again in the ante area before leaving the sterile compounding area.