Haplotypes I Flashcards
What haplotype is expressed by approximately 70% of patients with rheumatoid arthritis?
HLA-DR4
What haplotype is expressed by patients with Ankylosing spondylitis?
HLA-B27
What haplotype is expressed by patients with Dermatitis Herpetiformis?
HLA-DR3
What haplotype is expressed by patients with Reiters syndrome?
HLA-B27
What haplotype is expressed by patients with Insulin-dependent diabetes?
HLA DR3/ HLA DR4
What haplotype is expressed by patients with Psoriasis vulgaris?
HLA-C6
What haplotype is expressed by patients with Goodpasture’s syndrome?
HLA-DR2
What haplotype is expressed by patients with SLE?
HLA-DR2
What haplotype is expressed by patients with pernicious anemia?
HLA-DR5
What conditions are characterized by HLA-B27 haplotypes?
Psoriasis, Ankylosing spondylitis, Inflammatory Bowel Disease, Reiters syndrome (acronym: PAIR) (p.194)
What conditions are characterized by HLA-DR3 haplotypes?
Dermatitis herpetiformis, Insulin-dependent diabetes, Grave’s Disease (p.194)
What conditions are characterized by HLA-DR4 haplotypes?
Insulin dependent diabetes, Rheumatoid arthritis (p.194)
Where are Class I HLA antigens found?
On all nucleated cells.
What gene loci distinguish HLA Class I antigens?
HLA-A, HLA-B, HLA-C
What is the function of HLA Class I antigens?
To present foreign antigenic peptides to CD8+ T cells.
Where are class II HLA antigens found?
On immunologic effector cells (ex. macrophages, DCs, B cells, activated epithelial cells, etc.)
What gene loci distinguish HLA Class II antigens?
HLA-DP, HLA-DQ, HLA-DR
On what chromosome are genes for the HLAs of MHCs encoded?
Chromosome 6.
What is the function of HLA Class II antigens?
To present foreign antigenic peptides to CD4+ T cells.
