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Immunology > Cytokines, Interferons, Cell Surface Molecules II > Flashcards

Cytokines, Interferons, Cell Surface Molecules II Flashcards

1
Q

What CD markers are ubiquitous to all cells?

A

CD54, CD58

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2
Q

What CD marker is expressed exclusively by NK cells?

A

CD56

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3
Q

What CD cell type mediated leukocyte adhesion and rolling interaction with the endothelium?

A

CD82L

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4
Q

Which cell types possess CD82L?

A

B cells, T cells, monocytes, NK cells.

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5
Q

What CD cell type is a high affinity receptor for IgG?

A

CD64

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6
Q

What CD cell type is a receptor for IgA?

A

CD89

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7
Q

What CD cell type is ubiquitous to all proliferating (i.e. activated cells)?

A

CD71

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8
Q

What CD cell type is unique to lymphocytes?

A

CD81

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9
Q

What type of cells express CD80 antigens?

A

B cells.

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10
Q

What cell marker is used to count T cells?

A

CD3

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11
Q

What cell markers are used to count B cells?

A

Membrane bound IgM, CD19, CD20.

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12
Q

A deficiency in what CD cell type is associated with Leukocyte Adhesion Deficiency?

A

CD18 integrin.

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13
Q

What important cytokines are secreted by macrophages?

A

IL-1, IL-6, IL-8, IL-12, TNFa (p.200)

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14
Q

Name four functions of IL-1.

A

1.) endogenous pyrogen- causes fever; 2.) causes acute inflammation; 3.) activates endothelium to express adhesion molecules; 4.) induces chemokine secretion to recruit leukocytes (p.200)

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15
Q

What is the function of IL-6?

A

An endogenous pyrogen that causes fever and stimulates production of acute phase proteins (p.200)

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16
Q

What cell type secretes IL-6?

A

Th2 cells (p.200)

17
Q

Describe the principle functions of cytokines IL-1 through IL-5.

A

(Hot T-Bone stEAk) IL-1: fever (hot); IL-2: stimulates T cells; IL-3: stimulates Bone marrow; IL-4: stimulates IgE production; IL-5: stimulates IgA production (p.200)

18
Q

What is the major function of IL-8?

A

IL-8 is the major chemotactic factor for neutrophils; IL-8 helps clear infections (p.200)

19
Q

What are the two major functions of IL-12?

A

To induce differentiation of T cells into Th1 cells and to activate NK cells (p.200)

20
Q

What cell type secretes IL-12?

A

IL-12 is secreted by B cells (p.200)

21
Q

What are the four major functions of TNF-a?

A

Mediation of septic shock, activation of endothelium, leukocyte recruitment, vascular leak (p.200)

22
Q

What two cytokines are secreted by all T cells?

A

IL-2 and IL-3 (p.200)

23
Q

From where is IFN-y secreted?

A

From Th1 cells (p.200)

24
Q

What is secreted from Th2 cells?

A

IL-4, IL-5, IL-10, IL-13 (p.200)

25
Q

What is the function of IL-2?

A

Stimulates growth of helper, cytotoxic, and regulatory T cells (p.200)

26
Q

What is the function of IL-3?

A

Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF (p.200)

Immunology (28 decks)

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