Cytokines, Interferons, Cell Surface Molecules II

Question 1

What CD markers are ubiquitous to all cells?

Answer 1

CD54, CD58

Question 2

What CD marker is expressed exclusively by NK cells?

Answer 2

CD56

Question 3

What CD cell type mediated leukocyte adhesion and rolling interaction with the endothelium?

Answer 3

CD82L

Question 4

Which cell types possess CD82L?

Answer 4

B cells, T cells, monocytes, NK cells.

Question 5

What CD cell type is a high affinity receptor for IgG?

Answer 5

CD64

Question 6

What CD cell type is a receptor for IgA?

Answer 6

CD89

Question 7

What CD cell type is ubiquitous to all proliferating (i.e. activated cells)?

Answer 7

CD71

Question 8

What CD cell type is unique to lymphocytes?

Answer 8

CD81

Question 9

What type of cells express CD80 antigens?

Answer 9

B cells.

Question 10

What cell marker is used to count T cells?

Answer 10

CD3

Question 11

What cell markers are used to count B cells?

Answer 11

Membrane bound IgM, CD19, CD20.

Question 12

A deficiency in what CD cell type is associated with Leukocyte Adhesion Deficiency?

Answer 12

CD18 integrin.

Question 13

What important cytokines are secreted by macrophages?

Answer 13

IL-1, IL-6, IL-8, IL-12, TNFa (p.200)

Question 14

Name four functions of IL-1.

Answer 14

1.) endogenous pyrogen- causes fever; 2.) causes acute inflammation; 3.) activates endothelium to express adhesion molecules; 4.) induces chemokine secretion to recruit leukocytes (p.200)

Question 15

What is the function of IL-6?

Answer 15

An endogenous pyrogen that causes fever and stimulates production of acute phase proteins (p.200)

Question 16

What cell type secretes IL-6?

Answer 16

Th2 cells (p.200)

Question 17

Describe the principle functions of cytokines IL-1 through IL-5.

Answer 17

(Hot T-Bone stEAk) IL-1: fever (hot); IL-2: stimulates T cells; IL-3: stimulates Bone marrow; IL-4: stimulates IgE production; IL-5: stimulates IgA production (p.200)

Question 18

What is the major function of IL-8?

Answer 18

IL-8 is the major chemotactic factor for neutrophils; IL-8 helps clear infections (p.200)

Question 19

What are the two major functions of IL-12?

Answer 19

To induce differentiation of T cells into Th1 cells and to activate NK cells (p.200)

Question 20

What cell type secretes IL-12?

Answer 20

IL-12 is secreted by B cells (p.200)

Question 21

What are the four major functions of TNF-a?

Answer 21

Mediation of septic shock, activation of endothelium, leukocyte recruitment, vascular leak (p.200)

Question 22

What two cytokines are secreted by all T cells?

Answer 22

IL-2 and IL-3 (p.200)

Question 23

From where is IFN-y secreted?

Answer 23

From Th1 cells (p.200)

Question 24

What is secreted from Th2 cells?

Answer 24

IL-4, IL-5, IL-10, IL-13 (p.200)

Question 25

What is the function of IL-2?

Answer 25

Stimulates growth of helper, cytotoxic, and regulatory T cells (p.200)

Question 26

What is the function of IL-3?

Answer 26

Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF (p.200)