Hallucinogens

Question 1

4 major classes of hallucinogens

Answer 1

1. 5-HT hallucinogens
2. Methylated amphetamines
3. Anticholinergic hallucinogens
4. Dissociative anesthetics

Question 2

Some examples of 5-HT hallucinogens

Answer 2

LSD, psilocybin, mescaline

Question 3

Which drug is very water soluble and easily crosses the BBB?

Answer 3

LSD

Question 4

3 routes of admin for LSD

Answer 4

Oral, sublingual, transdermal

Question 5

Route of admin for psilocybin

Answer 5

Oral, commonly as a tea

Question 6

2 routes of admin for Mescaline

Answer 6

Oral and inhalation

Question 7

Effects of psilocybin

Answer 7

Stronger hallucinations than LSD
Mood changes less intense than LSD
At high doses: time distortions, changes in body perception

Question 8

Common effects of hallucinogens (4)

Answer 8

Sensory disturbances
Altered perceptions
Effects on mood and cognition
Physiological effects

Question 9

2 main dissociative anesthetics

Answer 9

PCP and ketamine

Question 10

Which hallucinogen was originally developed as an anesthetic?

Answer 10

PCP

Question 11

Which hallucinogen resembles a schizophrenic state?

Answer 11

PCP

Question 12

Symptoms of PCP

Answer 12

Agitation
Excitement
Delirium
Disorientation
Hallucinations

Question 13

Effects of ketamine at high and low doses

Answer 13

Low: hallcinations
High: anesthetic state and amnesia

Question 14

Dissociative anesthetics are antagonists to which NT?

Answer 14

Glutamate

Question 15

Which hallucinogen is FDA approved for MDD?

Answer 15

Ketamine

Question 16

What effects did the ketamine rat show?

Answer 16

Pleasant floating
Respiratory depression at high doses
Uncoordination
High dose rat had zero stability on balance board test
Did not right self well in righting reflex test

Question 17

Which toad elicits DMT from their pores?

Answer 17

Colorado River Toad

Question 18

What hallucinogen is present in a small amount in the human brain with an unknown function?

Answer 18

DMT