CH 6: High Efficacy Stimulants

Question 1

What 4 drug types are classified as high efficacy?

Answer 1

Cocaine + derivatives, amphetamines + derivatives, amphetamine-like, and cathinone

Question 2

Current medicinal uses of cocaine and its derivatives

Answer 2

• used for nasal surgery as a topical solution

- derivatives (novacaine, etc.) used as local anesthetics

Question 3

Current medicinal uses of amphetamines

Answer 3

• ADHD treatment

- narcolepsy occasionally

Question 4

What drug was previously prescribed for weight loss?

Answer 4

Amphetamines

Question 5

What drug did Hitler take that possibly caused his tremor?

Answer 5

Meth (IV)

Question 6

What drug’s use started to decline in the early 1900s and why?

Answer 6

Cocaine, people discovered it could cause hallucinations and psychosis

Question 7

What drug’s use started to decline in the 1960s and why?

Answer 7

Amphetamines, people realized its addiction levels

Question 8

What drugs’ use increased in the late 90s?

Answer 8

Meth and MDMA

Question 9

Mechanism of action of cocaine

Answer 9

Blocks DA reuptake

Question 10

Mechanism of action of amphetamines

Answer 10

Blocks DA reuptake

Question 11

Mechanism of action of meth

Answer 11

Blocks DA reuptake and reverses transport and increases DA release

Question 12

Mechanism of action of MDMA

Answer 12

Blocks transporters and increases release of monoamines, especially 5-HT

Question 13

Risks of high stimulant doses

Answer 13

• drug-induced psychosis
• stereotyped behaviors (rocking, hair-pulling, etc.)
• OD/death

Question 14

What drug do its users say have never experienced the same high as the first time?

Answer 14

Meth.