hallucinogens

Question 1

what are classical psychedelics

Answer 1

perception altering psychedelic effects

Question 2

what are lysergamides

Answer 2

made from ergot alkaloids

Question 3

where are hallucinogenic effects of LSD mediated by

Answer 3

5HT-2a (partial agonist)

Question 4

why are all 5HT-2A agonists not hallucinogenic

Answer 4

biased agonism (LSD activates phospholipase A2)

Question 5

What was the function of Ketanserin

Answer 5

it is an antagonist at 5HT-2A and blocked hallucinogenic effects of LSD

Question 6

what is psilocybin

Answer 6

in mushrooms

Question 7

psilocybin is structurally similar to what monoamine

Answer 7

serotonin

Question 8

what kind if drug is psilocybin

Answer 8

prodrug to psilocin

Question 9

how does psilocin react at 5HT receptors

Answer 9

partial agonist

Question 10

describe psilocin affinity for 5HT

Answer 10

5HTb and c = high

5HTa = low

Question 11

what kind of hallucinogen is phencyclidine

Answer 11

dissosiative

Question 12

what is phencylclidine mechanisism

Answer 12

NMDA receptor antagonist

inhibitor at dopamine transporter

Question 13

what kind of hallucinogen is nitrous oxide

Answer 13

dissociative

Question 14

what is nitrous oxide mechanism of action

Answer 14

noncompetivie NMDA antagonist
stimulate endogenous opioid release
positive allosteric modulator at GABA receptors

Question 15

what do deliriant hallucinogen tend to block

Answer 15

muscaniric acetylcholine receptors

Question 16

what tropane alkaloids are found in datura stranmonium

Answer 16

scopolamine and atropine

Question 17

where do atoprine and scopolamine act

Answer 17

competitive antagonist at muscaniric cholinergic receptors