depression Flashcards
What system is implicated in emotions
limbic system
what system is implicated in motivation
mesocorticolimbic dopamine system
What other parts of the brain are included in the limbic brain?
amygdala, hippocampus, basal ganglia, cingulate gyrus
In a person with MDD, describe engagement of the limbic regions and motivational regions
increased engagement in limbic
decreased in motivational (striatum)
Which neurotransmitters are implicated in the amine hypothesis of depression?
dopamine, norepinephrine, seotonin (monoaminergic)
What may cause depression by inadequate monoamine neurotransmission?
less neurotransmitter release
fewer receptors
impaired signal transduction
What is reserpine and how does it cause depression?
hypertensive drug
depletes neurons of dopamine and norepinephriine transmitters
What is ipronazid and how does it work?
Inhibits monoamine oxidase which breakdowns monoamines, alleviating repression
What does the glutamate hypothesis suggest?
reduction in glutamatergic signalling in cortex
Which drug must be taken with a low tyramine diet?
ipronazid
What SSRIs?
selective seratonin reuptake inhibitors
What SNRIs?
serotonin norepinephrine reuptake inhibitors
What is an example of a selective reuptake inhibitor
fluoxetine
What us ketamine
noncompetitive NMDA receptor antagonist
What is the major side effect of ketamine
hallucinogenic
