antibiotics

Question 1

what is N-acetylglucosamine and N-acetylmuramic acid

Answer 1

makes up the glycan strands in peptidogylcan

Question 2

what is glyosyltransferase

Answer 2

polymerizes indivdual strands in peptidoglycan

Question 3

what is transpeptidase

Answer 3

cross link strands of peptidoglycan

Question 4

what is a bacterocidal antibiotic

Answer 4

permanent loss of replicative ability of bacteria

Question 5

what is bacteriostatic antibiotic

Answer 5

temporary loss of growth and replication

Question 6

what are the 4 classes of antibiotics

Answer 6

cell wall inhibitors
folic acid
DNA synthesis inhibitors
protein synthesis inhibitors

Question 7

what is penicillin mechanism of action

Answer 7

inhibts an enzyme DD-transpeptidase which is responsible for cross-linking components of cell wall

Question 8

what is another name DD transpeptidase?

Answer 8

penicillin binding protein

Question 9

what are penicillins and cephalosporins called

Answer 9

beta lactams

Question 10

what are beta lactamases

Answer 10

hydrolyze the beta-lactam

Question 11

what are beta-lactamase inhibitors

Answer 11

inhibit beta-lactamases

Question 12

what is vancomycin

Answer 12

inhibits peptidoglycan cross linking

Question 13

what are sulfonamides and trimethoprim

Answer 13

resemble para-aminobenzoic acid and interfere with pathway to folic acid

Question 14

what is chloramphenicol and macrolide

Answer 14

protein synthesis inhibitor

Question 15

where do chloramphenicol and macrolides bind

Answer 15

50S

Question 16

where do tetracyclines bind

Answer 16

30s subunit

Question 17

what are aminoglycosides

Answer 17

bind 30s ribosomal subunit

Question 18

what is caused stevens-johnson syndrome

Answer 18

skin becomes detached from body