Haemoglobin Flashcards
1
Q
T state
A
Low affinity Harder for Oxygen to bind Unload more Gap Taught - less movement of polypeptide chain
2
Q
R state
A
High affinity
More oxygen bound (loaded)
Relaxed - polypeptide movement
Cooperative binding
3
Q
2,3 bisphosphoglycerate
A
Lower affinity
T state
Unload more
Shifts to right
4
Q
Bohr effect
A
Co2 acidic
Decreases affinity
T state
Unload more
5
Q
Sickle cell anemia
A
Babies do not get sickle cell anaemia as do not have beta haemoglobin
Glutamate to valine missense
Valine hydrophobic clump together
