Haematopoeisis

Question 1

what makes up the hemopoietic system

Answer 1

bone marrow, liver, spleen, lymph nodes, thymus

Question 2

where is the source of blood cells in a normal adult? when is this not the case?

Answer 2

bone marrow

pathological processes interfering with normal hemopoeisis may result in haemopoiteic activity in the liver and spleen (extramedullary hemopoeisis)

Question 3

what hormone controls erythropoeisis? when is this increased

Answer 3

erythropoeitin (EPO) produced in kidneys

increased production with hypoxia

Question 4

what are the two cell lines coming from multipotential hematopoeitic cells

Answer 4

• myeloid –> (megakaryocyte (–> thrombocytes), erythrocyte, mast cells, myeloblast ) then myeloblast –> basophil, neutrophil, eosinophil, monocyte (–> macrophage)
• lymphoid –> natural killer cell and small lymphocyte. small lymphocyte –> T lymphocyte, B lymphocyte (–> plasma cell)

Question 5

what are blasts

Answer 5

In the myeloid cell line, the term “blast cell” refers to myeloblasts or myeloid blasts. These are the very earliest and most immature cells of the myeloid cell line.

Question 6

what bones carry out haematopoeisis in adults

Answer 6

axial skeleton and proximal heads of humerus and femur

Question 7

what is haematopoesis

Answer 7

Hematopoiesis is the production of all of the cellular components of blood and blood plasma.

eg all RBC, WC, platelts

Question 8

migration of haematopoeisis fetus, child, adult

Answer 8

In humans, hematopoiesis begins in the yolk sac and transitions into the liver temporarily before finally establishing definitive hematopoiesis in the bone marrow and thymus.

In adults, hematopoiesis of red blood cells and platelets occurs primarily in the bone marrow. In infants and children, it may also continue in the spleen and liver. The lymph system, particularly the spleen, lymph nodes, and thymus, produces a type of white blood cell called lymphocytes.