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Radiology > Haematology > Flashcards

Haematology Flashcards

1
Q

What is Waterhouse-Friedrichsen syndrome?

A

Form of DIC

Massive adrenal haemorrhages in meningococcaemia

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2
Q

Sheehan syndrome?

A

Post-partum pituitary necrosis

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3
Q

What causes HUS in children?

A

Verocytotoxin-producing E.Coli: endothelial effects

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4
Q

3 major types of haematological malignancies?

A

Lymphoid: lymphoma, leukaemia, plasma cell neoplasm

Myeloid: ALL, myeloproliferative disorders (PRV, ET, CML), myelofibrosis

Histiocytoses: LCH, Erdeim-Chester

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5
Q

What is Bart’s hydrops?

A

Severe form of alpha-thalassaemia

Deletion of all 4 alpha-globin genes

Excess gamma-globin forming HbBarts tetramers with very high oxygen affinity

Severe tissue anoxia and lethal in utero

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6
Q

Most common NHL in kids and adults?

A

Kids: ALL and Burkitt

Adults: DLBCL, follicular lymphoma

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7
Q

SLL vs CLL

A

Both have small B-lymphocytes

Differ by degree of peripheral lymphocytosis

23-40% transform into more aggressive DLBCL

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8
Q

What is extranodal MZL also called?

A

MALT lymphoma (lymphoepithelial lesion)

Associated with inflammatory and autoimmune conditions:

Stomach (H.Pylori)

Thyroid (Hashimoto)

Salivary gland (Sjögren)

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9
Q

Peak age for HL?

A

Bimodal: 25 and 75

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10
Q

Best and worst Px HD subtypes?

A

Best: lymphocyte predominant (80% 10 YS)

Worst: lymphocyte depleted (5% 10 YS)

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11
Q

Which leukaemia has granular cytoplasm and Auer rods?

A

AML

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12
Q

Most common pathology behind myeloproliferative disorders?

A

Mutated, hyperactive tyrosine kinase (JAK-2 mutation)

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13
Q

MGUS vs Waldenstrom’s macroglobulinaemia

A

MGUS: benign tumour of B-cells with paraproteinaemia

WM: lymphomplasmacytoid malignancy- IgM paraproteinaemia and hyperviscosity

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14
Q

What is POEMS syndrome?

A

Atypical form of myeloma

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes

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15
Q

Langerhans cells on EM?

A

Birbeck granules

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16
Q

Name the 3 grades of thymoma.

A

Non-invasive (encapsulated)

Invasive thymoma (invasion of mediastinum, chest wall and pleura)

Thymic carcinoma (mostly SCC)

17
Q

Is mycosis fungoides associated with EBV?

A

No. Cutaneous T-cell lymphoma

18
Q

Hodgkins disease and EBV?

A

Associated with 40-80%

19
Q

Is mycosis fungoides associated with EBV?

A

No. Cutaneous T-cell lymphoma

20
Q

Hodgkins disease and EBV?

A

Associated with 40-80%

21
Q

Aplastic crisis in Sickle cell and HS?

A

Infection with parvovirus B19

Reticulocytes destroyed by virus

22
Q

Nuc Med scan to confirm EMH?

A

Tc 99m sulphur colloid

23
Q

Top 3 causes of splenic miliary nodules (siderosis)

A

Portal HTN

Leukaemia/ lymphoma

Haemolysis/ sickle cell

24
Q

PET negative lymphoma?

A

T-cell lymphoma

Radiology (16 decks)

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