Haematology Flashcards
What is the most commonly inherited clotting disorder and its mode of inheritance?
Von Willebrand’s factor
Mostly autosomal dominant
What would coag results look like in haemophilia?
1) Prolonged APTT
2) BT, TT and PT all normal
What do blood parameters look like in DIC?
↓ platelets
↓ fibrinogen
↑ PT & APTT
↑ fibrinogen degradation products
High D-dimer
low platelets
What would coag results look like in Von Willebrand’s disease?
1) Prolonged bleeding time
2) APTT may be prolonged
Normal platelets
What is the most common inherited thrombophilia?
Factor V Leiden
What would blood tests show in tumour lysis syndrome? Prophylaxis?
High potassium
High phosphate
Low calcium
Management: allopurinol or rasburicase
Why use irradiated blood?
To avoid transfusion-associated graft versus host disease
FBC results in sickle cell anaemia?
Low Hb
Normal MCV
Raised reticulocytes
haemolytic anaemia
What is the single most important factor in determining whether cryoprecipitate should be given?
A low fibrinogen level
What are signs of hyposplenism on a blood film?
Hyposplenism (post-splenectomy, coeliac disease)
target cells
Howell-Jolly bodies
Pappenheimer bodies
siderotic granules
acanthocytes
What are the signs of IDA on blood film?
target cells
‘pencil’ poikilocytes
if combined with B12/folate deficiency a ‘dimorphic’ film occurs with mixed microcytic and macrocytic cells
What is the sign of myelofibrosis on blood film?
‘tear-drop’ poikilocytes
What is the sign of intravascular haemolysis on blood film?
Schistocytes
What is the sign of megaloblastic anaemia on blood film?
hypersegmented neutrophils
