Haematology

Question 1

CLL

Answer 1

B-cell lymphoma that presents with lymphocytosis.

Most common leukaemia in adults.

Blood film: small mature lymphocytes and smudge cells.

Question 2

CML

Answer 2

Excessive proliferation of myeloids, especially granulocytes.

Philadelphia chromosome 22 mutation.

Treatment: Imatinib (tyrosine kinase inhibitor)

Question 3

vWD

Answer 3

Defiency in vWF leading to dysfunction in formation of platelet plug.

Question 4

Lab findings in vWD

Answer 4

Normal platelet count and morphology.

Prolonged bleeding time BUT normal PT and PTT

Question 5

Diagnosis of vWD
- Clinical findings
- Investigation

Answer 5

Clinical findings: FHx, prolonged bleeding but not deep tissue (haematoma)

Ristocetin cofactor assay

Question 6

Treatment of vWD

Answer 6

Desmopression - stimulated vWF from endothelial cells

Question 7

Lab findings in Haemophilia

Answer 7

Normal platelets
Normal PT
Isolated elevated aPTT