Haematinics Flashcards
microcytic anaemia
MCV<80fL iron deficiency anaemia of chronic disease copper deficiency acquired sideroblastic anaemia lead poisoning
normocytic anaemia
MCV 80-100fL acute haemorrhage or haemolysis renal failure anaemia of chronic disease combined nutritional deficiencies marrow disorders malignancy
microcytic anaemia
MCV>100fL hypothyroidism B12/folate deficiency liver disease ETOH compensated haemolysis/haemorrhage marrow disorder pregnancy drugs
treatment for iron deficiency
iron, oral or parenteral
treatment for renal failure
erythropoetin
B12/folate deficiency treatment
B12, folate
iron form more well absorbed
Fe2+ not Fe3+
acidic pH of stomach
reductive, maintains Fe2+
Fe in many foods is not absorbable because
it is complexed with phytates or phosphates
Fe replacement
oral
antacids
cause oxifation to Fe3+ making it not absorbable
iron preparations are best taken
on an empty stomach
antibiotics that complex with iron
tetracycline, and fluoquinolones
adverse effects of Fe
gastrointestinal intolerance
hypersensitivity
overdose of iron
serious, early GI irritation, later multi system failure and death