drug treatment of engine and acute coronary syndromes

Question 1

treatment for angina

Answer 1

beta adrenoceptor blockers

Ca+ channel blockers

Question 2

nitric oxide

Answer 2

released by endothelium

passes to the vascular smooth muscle of the arteriole which causes them to relax

Question 3

glyceryl trinitrate

Answer 3

supplies nitro oxide

nitrate groups removed by enzymes

Question 4

organic nitrate ester reductase

Answer 4

turns glyceryl trinitrate into nitric oxide

Question 5

nitrates can’t be given

Answer 5

orally

Question 6

tachyphylaxis

Answer 6

nitrates loses effect over time because of failure of reduction to NO

Question 7

anti platelet drugs

Answer 7

indicated in all forms of artery disease
clopidogrel
prasugrel and ticagrelor

Question 8

urgent thrombolysis

Answer 8

streptokinase or altepase

Question 9

beta adrenergic blockade

Answer 9

diminished rate of ventricular arrhythmia
suppressing heart rate and contractility
limits infarct size
helps pain

Question 10

long term secondary management of coronary artery disease

Answer 10

• limit adverse outcomes of myocardial infarction
• arrhythmia and sudden death
• recurrent myocardial infarction
• cardiac remodelling

Question 11

extrinsic clothing pathway uses

Answer 11

factors 7 and ten

Question 12

intrinsic clotting cascade uses

Answer 12

factors 12, 11, 9, 10

Question 13

factor 12 is activated by

Answer 13

abnormal cell wall

Question 14

factor 10 converts

Answer 14

prothrombin into thrombin

Question 15

thrombin fibrin clot made from

Answer 15

thrombin and fibrinogen

Question 16

decarboxy-prothrombin

Answer 16

must be converted to prothrombin by a carboxylase enzyme

Question 17

warfarin inhibits

Answer 17

vitamin E epoxide reductase complex 1 (VKORC1)

Question 18

protein S and protein C veritable deficiency

Answer 18

causes hypercoagulable state causing necrosis of skin

Question 19

heparin

Answer 19

not teratogenic

works immediately

Question 20

direct enzyme inhibitors

Answer 20

dabigatran and rivaroxaban