Haem Flashcards
What is the treatement for DVT?
immediate lmwh or fondaparinux for atleast 5 days
warfarin for 3 months if provoked or 6 months if unprovoked.
unpovoked DVT should be investigated for unlying malignancy - physical, CXR, bloods(FBC, Calcium, LFT, UE)
myeloma
high total protein, renal failure, hypercalcaemia
commonly present with back and bone pain - do an ESR/serum electrophoresis
why is there an increased risk of stroke in myeloma?
paraproteinaemia causes hyperviscosity even thought there is a pancytopenia (anaemia, thrombocytopenia, neutropenia)
which drugs precipitate G6PD?
cipro
sulpha-
antimalarials - primaquine
post thrombotic syndrome?
essentialy varicose veins and the associated problems after a DVT due to increased venous pressures. deep vein insufficicney
post thrombotic syndrome?
essentialy varicose veins and the associated problems after a DVT due to increased venous pressures. deep vein insufficicney
How might sickle cell present?
SICKLED Splenomegaly Infarction - stroke/spleen/ulcers/AVN Crisis - painful, chest, mesenteric Kidny disease Liver/lung Erection Dactylitis
severe complications of sickle cell
infarctions
splenic sequestration
chest crisis
parvovirus infection- aplastic crisis
osteomyelitis
gallstones
How do you treat sickle cell?
hydroxycarbamide - works by increasing the concentration of foetal haemoglobin
decreases deoxyribonucleotide production
also give prophylactic antibiotics which target encapsulated organisms as they are hyposplenic
symptoms of lead poisoning?
peripheral motor neuropathy constipation abdo pain gum blue lines fatigue
philadelphia chromasome?
t9:22 95 % of CML
25% of ALL
common causes of tumour lysis syndrome
burkits
eosinophilia
hodgkins
medications which cause VTE?
olanzapine
tamoxifen
OCP 3 more than 2
HRT
Warm agglutinins?
IgG
