Gynae problems

Question 1

What type of colour inheritence pattern colour blindness?

Answer 1

X linked recessive

Question 2

What is inheritence pattern of kallman syndrome?

Answer 2

x linked recessive

Question 3

What is kallman syndrome?

Answer 3

defect kal-1 gene> dysgenesis of olfactory bulbs and < gnrh due to failure HPG axis

Leads to delayed puberty, anosmia, midline structural defects and mental retardation

Question 4

Swyer syndrome have the karyotype 46XY, but they have a uterus and tubes. What is defect?

Answer 4

Rare miutation SRY gene- gonaladal dysgenesis- no testes. External gentalia- female.

Question 5

Mayer–Rokitansky–Küster–Hauser- what is it?

Answer 5

Absent or rudimentary uterus
Normal sex characteristics
Normal karyotype

Question 6

Congential adrenal hyperplasia

Answer 6

Enzyme deficinecy in corticosteroid production

Question 7

Describe the four types of fgm

Answer 7

1- partial or total removal of clitoris/ prepuce
2- partial/ total removal of clitoria, labia minora +/- excision of labia majora
3- narrowing of vaginal oriface by apposition of cut edges of the labia minora +/- majora
4- other harmful procudures for non-medical purposes- e.g clitoral piercing

Question 8

Which virus should women with fgm be screened for?

Answer 8

hep c

Question 9

Which genital infections are associated with fgm?

Answer 9

BV and herpes HSV2

Question 10

Which year fgm act england and scotland?

Answer 10

2003, 2005

Question 11

When should fgm be reported in the police and how soon?

Answer 11

Any fgm < age 18, within 1 month

Question 12

Wat drives OHSS?

Answer 12

Exposure of ovaries to hcg/ LH (after stimulation by FSH) > proinflamatory mediators VEGF and cytokines

Question 13

What percentage of IVF affected by ohss?

Answer 13

33%

3-8% severe

Question 14

How would you expect U&Es to look in someone with ohss?

Answer 14

low na and high K

Question 15

Ovarian size mild, moderate and severe ohss?

Answer 15

mild <8
mod 8-12
severe >12

Question 16

Which analgesia should be avoided in OHSS?

Answer 16

NSAIDS

Question 17

When shouldparacentesisbe performed for ohss?

Answer 17

severe distension, sob with resp compromise, oliguria despite replacement

Question 18

What is the risk of miscarriage after 3 consecutive miscarriages?

Answer 18

40%

Question 19

What percentage of couples are affected by recurrent miscarriage?

Answer 19

1%

Question 20

Unexplained recurrent miscarriage will conceive with supportive care alone in what pergcentage?

Answer 20

75%

Question 21

What percentage of women with recurrent misc have apl abs?

Answer 21

15%

With no intervention- live birth rate just 10%

Question 22

Inherited thrombophillic diseases

Answer 22

activated protein c resistance
deficiencies in protein c ans s and antithrombin
Prothrombin gene mutation

Question 23

When should cervical cerclage be offered?

Answer 23

cx length <25mm

and prev pregnancy loss up to 34 weeks

Question 24

What are first line medications for bladder pain syndrome?

Answer 24

Amitryptaline, cimetadine

Question 25

What percentage of hysterectomies > vault prolapse?

Answer 25

11.6%

Question 26

What are the rotterdam criteria?

Answer 26

Clinical/ biochem features pcos
oligo/ amenorrhoea
ovaries > 12 follicles or > 10mls