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MFSRH Part 1 CM > Gynae > Flashcards

Gynae Flashcards

1
Q

Most important factor in cause of OHSS

A

VEGF-A

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2
Q

Most common gynae cancer

A

Endometrial cancer

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3
Q

Name estrogen secreting ovarian tumors

A

Granulosa cell tumors

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4
Q

Uterine thickness in MM for ruling out endometrial cancer

A

4mm

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5
Q

What blood tests for granulosa cell tumors

A

Inhibin and eastradiol

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6
Q

First line treatment for endometrial hyperplasia without atypia

A

Medical (usually), pref. LNG-IUS

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7
Q

First line treatment for endometrial hyperplasia with atypia

A

Hysterectomy +/- bilateral salpingo-oophrectomy

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8
Q

When does GTD become GTN

A

If hCG remains raised after primary treatment of GTD it becomes GTN

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9
Q

Does molar pregnancy require anti D

A

Complete molar no
Partial molar yes

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10
Q

OHSS blood results

A

Elevated heamatocrit
Reduced serum osmolality
Low sodium

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11
Q

Key features of granulosa cell tumors

A

Most common, esp in middle aged women
Have call-exner bodies - disarrayed granulose cells surrounded by small eosinophilic fluid filled spaces
Produce TONS of estrogen

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12
Q

Fibroma tumors?

A

Benign, from fibroblast cells
Associated with ascites
Needle like strands (long nuclei) on histology

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13
Q

Meigs syndrome?

A

Benign tumor, ascites, pleural effusion
(Fibroma)

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14
Q

Seroli-leydig tumors?

A

Look like the cells found in men
Produce testosterone (leading to hirsutism)
Reinke crystals(pink rod like crystals in cell cytoplasm) under microscope

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15
Q

What gynae conditions carry increased risk for ovarian cancer

A

Endometriosis
PCOS

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16
Q

What is a sister Mary Joseph nodule

A

(Ovarian (maybe)( cancer metastasis to the umbilicus

17
Q

Who is most at risk of epithelial cell ovarian tumors

A

Post menopausal, BRCA 1, lynch syndrome

18
Q

Histological feature of malignant ovarian epithelial tumours

A

Papillary projections (shaggy appearance)

19
Q

What histologic association is there with serous cystadenomas

A

Psammoma bodies

20
Q

What are psammoma bodies described as

A

Dystrophic calcifications
Calcific spherules, layered

21
Q

Brenner cyst?

A

Cyst lined with transitional bladder epithelium

22
Q

Dysgerminoma features

A

Premenopausal
“Fried egg” histology (large cells with clear cytoplasm and large nucleii)

23
Q

Dysgerminoma tumor markers

A

PLAP, bhcG, LDH

24
Q

Yolk sac tumor features

A

Young, usually child
Schiller-duval bodies (endodermal sinuses) resemble primitive glomeruli

25
Q

Yolk sac tumor marker

A

AFP

26
Q

Teratoma malignant transformation?

A

Squamous cell carcinoma

27
Q

What is struma ovarii

A

Adnexal mass + hyperthyroidism
(Teratoma with thyroid tissue)

28
Q

Krukenberg tumor?

A

Metastatic gi tumor
Signet ring cells - mucin cells displacing the nucleus

29
Q

PCOS LH FSH pattern

A

Raised LH normal FSH 3:1

MFSRH Part 1 CM (15 decks)

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